Ctsk - cathepsin K Gene

Mus musculus

Also known as catK; Ms10q; MMS10-Q

Gene ID: 13038 | Gene type: protein coding

About Ctsk

Chromosome 3: 95,406,567-95,416,673 forward strand.GRCm39:CM000996.3

This gene has 1 transcript (splice variant), 240 orthologues, 24 paralogues and is associated with 55 phenotypes. Biased expression in bladder adult (RPKM 27.4), limb E14.5 (RPKM 13.7) and 12 other tissues.

Summary

This gene encodes a member of the Cathepsin family of cysteine proteases that is highly expressed in osteoclasts and is involved in the degradation of collagen and Other matrix proteins in bone. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional Enzyme. Mice lacking the encoded protein exhibit phenotypic features of pycnodysostosis such as increased bone density and bone deformity, which become progressively more pronounced with age. [provided by RefSeq, Jan 2016]

Ctsk Products(1)

mRNA	Protein	Name
NM_007802.4	NP_031828.2	cathepsin K preproprotein

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within bone resorption	IMP IMP: Inferred from mutant phenotype	19834056	MGI
acts upstream of or within collagen catabolic process	IMP IMP: Inferred from mutant phenotype	19834056	MGI
acts upstream of or within negative regulation of cartilage development	IMP IMP: Inferred from mutant phenotype	19834056	MGI
involved in proteolysis involved in protein catabolic process	IMP IMP: Inferred from mutant phenotype	12782676	MGI
involved in thyroid hormone generation	IMP IMP: Inferred from mutant phenotype	12782676	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	12782676	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	12782676	MGI
located in lysosome	IDA IDA: Inferred from direct assay	12782676	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ctsk Protein Structure

Inhibitor_I29

Peptidase_C1

0
100
200
300
329 a.a.

Protein Preferred Names

Protein Names

cathepsin K

Cat K

Recombinant Ctsk Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72157	Cathepsin K Protein, Mouse (His)	P55097 (V115-M329)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-143714	Cathepsin K inhibitor 2	Inhibitor	/	Unkown
HY-155960	SH491		/	Unkown
HY-RS03337	CTSK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03338	Ctsk Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03339	Ctsk Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ctsk	NCBI	NCBI:1513
Rattus norvegicus	Ctsk	NCBI	NCBI:29175

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