2. Gene
  3. ADH7 - alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Gene

ADH7 - alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ADH4

Gene ID: 131 | Gene type: protein coding

About ADH7

Cytogenetic location: 4q23 Genomic coordinates (GRCh38): 4:99,412,263-99,435,342 (from NCBI)

This gene has 6 transcripts (splice variants), 350 orthologues and 17 paralogues. Restricted expression toward esophagus (RPKM 95.5).

Summary

This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The Enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

ADH7 Products(2)

mRNA Protein Name
NM_000673.7 NP_000664.3 all-trans-retinol dehydrogenase [NAD(+)] ADH7 isoform 2
NM_001166504.2 NP_001159976.1 all-trans-retinol dehydrogenase [NAD(+)] ADH7 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables alcohol dehydrogenase (NAD+) activity IDA
IDA: Inferred from direct assay
7876099 GOA
enables aldehyde oxidase activity IDA
IDA: Inferred from direct assay
9600267 GOA
enables all-trans-retinol dehydrogenase (NAD+) activity IDA
IDA: Inferred from direct assay
7876099 GOA
enables ethanol binding IDA
IDA: Inferred from direct assay
9228021 GOA
enables receptor antagonist activity IDA
IDA: Inferred from direct assay
9600267 GOA
enables retinol binding IDA
IDA: Inferred from direct assay
9228021 GOA
Biological Process GO Annotation Evidence Reference Source
involved in fatty acid omega-oxidation IDA
IDA: Inferred from direct assay
9600267 GOA
involved in response to bacterium IDA
IDA: Inferred from direct assay
11410738 GOA
involved in response to ethanol IDA
IDA: Inferred from direct assay
9600267 GOA
involved in retinoid metabolic process IDA
IDA: Inferred from direct assay
9600267 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADH7 Protein Structure

ADH_N

ADH_N: Alcohol dehydrogenase GroES-like domain (47 - 172)

ADH_zinc_N

ADH_zinc_N: Zinc-binding dehydrogenase (214 - 343)

  • 0
  • 100
  • 200
  • 300
  • 386 a.a.
Protein Preferred Names Protein Names

all-trans-retinol dehydrogenase [NAD(+)] ADH7

alcohol dehydrogenase VII

Recombinant ADH7 Proteins

Cat. No. Product Name Accession Purity
HY-P7473 ADH7 Protein, Human (HEK293, His) P40394 (M1-F386) ≥95%

Related Diseases

Diseases Alias
Alcohol Dependence

Alcoholism

Alcohol Dependence, Susceptibility To

Alcohol Dependence, Protection Against

Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

Alcoholism, Susceptibility To

Alcoholic Intoxication, Chronic

Pharyngeal Neoplasms

Chronic Alcoholism

Dipsomania

Alcohol Addiction

Ethanol Dependence

Chronic Ethanolism

Chronic Alcoholic Disease Nos

Alcoholic Disease Nos

Alcoholic
Atrophic Gastritis

Gastritis, Atrophic

Gastric Atrophy

Gastritis Atrophic
Gastritis

Acute Gastric Mucosal Erosion

Erosive Gastritis

Erosive Gastropathy

Gastritis Erosive

Idiopathic Erosive/Hemorrhagic Gastritis

Inflammation Of Gastric Mucosa

Gastroduodenitis

Gastritis Nos

Noninfectious Gastroenteritis

Nonbacterial Gastroenteritis Of Infant

Acute Gastric Infection

Acute Simple Gastritis

Chronic Antral Gastritis

Chronic Fundal Gastritis

Chronic Simple Gastritis

Acute Gastroduodenitis

Acute Antral Gastritis

Acute Erosive Gastritis

Bile Reflux Gastritis

Gastritis Due To Biliary Reflux
Fetal Alcohol Syndrome

Fetal Alcohol Spectrum Disorders

Arbd

Arnd

Alcohol-Related Birth Defects

Alcohol-Related Neurodevelopmental Disorder

Fas

Fasd

Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta Or Breast Milk

Alcohol Related Birth Defect

Alcohol Related Neurodevelopmental Disorder

Alcohol Affecting Fetus Or Newborn Via Placenta Or Breast Milk

Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta And/Or Breast Milk

Dysmorphism Due To Alcohol

Fetal Etoh Syndrome
Alcoholic Cardiomyopathy

Cardiomyopathy, Alcoholic

Alcohol-Induced Heart Muscle Disease

Dilated Cardiomyopathy Secondary To Alcohol
Substance Dependence
Fetal Alcohol Spectrum Disorder

Fetal Alcohol Spectrum Disorders

Fetal Alcohol Syndrome
Alcohol Use Disorder

Alcohol Abuse

Alcoholism

Ethanol Abuse

Alcohol Addiction

Alcohol Dependence

Alcoholic Intoxication, Chronic

Alcohol-Related Disorders
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00374 ADH7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ADH7 RGD RGD:621638
Mus musculus ADH7 MGD MGI:87926