LRRC15 - leucine rich repeat containing 15 Gene

Homo sapiens

Also known as LIB

Gene ID: 131578 | Gene type: protein coding

About LRRC15

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:194,355,249-194,369,743 (from NCBI)

This gene has 2 transcripts (splice variants), 112 orthologues and 22 paralogues. Broad expression in endometrium (RPKM 1.9), gall bladder (RPKM 1.2) and 15 other tissues.

Summary

Enables collagen binding activity; fibronectin binding activity; and laminin binding activity. Involved in negative regulation of protein localization to plasma membrane; positive regulation of cell migration; and receptor-mediated virion attachment to host cell. Located in extracellular exosome. Colocalizes with collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022]

LRRC15 Products(2)

mRNA	Protein	Name
NM_001135057.3	NP_001128529.2	leucine-rich repeat-containing protein 15 isoform a precursor
NM_130830.5	NP_570843.2	leucine-rich repeat-containing protein 15 isoform b precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables collagen binding	IDA IDA: Inferred from direct assay	16098915	GOA
enables fibronectin binding	IDA IDA: Inferred from direct assay	16098915	GOA
enables laminin binding	IDA IDA: Inferred from direct assay	16098915	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	36228039	GOA
enables protein sequestering activity	IDA IDA: Inferred from direct assay	36228039	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	18385238	GOA
involved in negative regulation of viral entry into host cell	IDA IDA: Inferred from direct assay	36228039	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	16098915	GOA
involved in receptor-mediated virion attachment to host cell	IDA IDA: Inferred from direct assay	36228039	GOA
involved in receptor-mediated virion attachment to host cell	IMP IMP: Inferred from mutant phenotype	18385238	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in apical plasma membrane	IDA IDA: Inferred from direct assay	36228039	GOA
colocalizes with collagen-containing extracellular matrix	IDA IDA: Inferred from direct assay	16098915	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	36228039	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRRC15 Protein Structure

LRR_8

LRR_1

LRR_8

LRR_4

LRR_8

0
100
200
300
400
500
581 a.a.

Protein Preferred Names

Protein Names

leucine-rich repeat-containing protein 15

hLib

Recombinant LRRC15 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72512	LRRC15 Protein, Human (HEK293, His)	Q8TF66-1 (Y22-G538)	≥95%
HY-P76480	LRRC15 Protein, Human (HEK293, Fc)	Q8TF66-1 (Y22-G538)	≥95%
HY-P78172	LRRC15 Protein, Human (Biotinylated, HEK293, His-Avi)	Q8TF66-1 (Y22-G538)	≥95%
HY-P78486	LRRC15 Protein, Human (HEK293, His-Avi)	Q8TF66-1 (Y22-G538)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07808	LRRC15 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LRRC15	VGNC	VGNC:97483
Bos taurus	LRRC15	VGNC	VGNC:31001
Rattus norvegicus	LRRC15	RGD	RGD:70551
Macaca mulatta	LRRC15	VGNC	VGNC:74322
Canis familiaris	LRRC15	VGNC	VGNC:42786
Mus musculus	LRRC15	MGD	MGI:1921738
Macaca fascicularis	LRRC15	NCBI	NCBI:102144360
Others	LRRC15	NCBI

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