SLC31A1 - solute carrier family 31 member 1 Gene

Homo sapiens

Also known as CTR1; COPT1

Gene ID: 1317 | Gene type: protein coding

About SLC31A1

Cytogenetic location: 9q32 Genomic coordinates (GRCh38): 9:113,221,544-113,264,492 (from NCBI)

This gene has 2 transcripts (splice variants), 215 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in liver (RPKM 33.0), duodenum (RPKM 22.8) and 25 other tissues.

Summary

The protein encoded by this gene is a high-affinity copper transporter found in the cell membrane. The encoded protein functions as a homotrimer to effect the uptake of dietary copper. [provided by RefSeq, Aug 2011]

SLC31A1 Products(1)

mRNA	Protein	Name
NM_001859.4	NP_001850.1	high affinity copper uptake protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables copper ion binding	IDA IDA: Inferred from direct assay	26745413	GOA
enables copper ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	11734551	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16501047	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24837030	GOA
enables silver ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	20569931	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in angiogenesis	IMP IMP: Inferred from mutant phenotype	35027734	GOA
involved in copper ion import	IDA IDA: Inferred from direct assay	16135512	GOA
involved in plasma membrane copper ion transport	IDA IDA: Inferred from direct assay	11734551	GOA
involved in protein complex oligomerization	IDA IDA: Inferred from direct assay	15326162	GOA
involved in silver ion transmembrane transport	IDA IDA: Inferred from direct assay	20569931	GOA
involved in vascular endothelial growth factor receptor-2 signaling pathway	IMP IMP: Inferred from mutant phenotype	35027734	GOA
involved in xenobiotic transport	IDA IDA: Inferred from direct assay	20451502	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in early endosome membrane	IDA IDA: Inferred from direct assay	26945057	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	11734551	GOA
located in recycling endosome membrane	IDA IDA: Inferred from direct assay	26945057	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC31A1 Protein Structure

Ctr

0
100
190 a.a.

Protein Preferred Names

Protein Names

high affinity copper uptake protein 1

copper transport 1 homolog

Recombinant SLC31A1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72011	SLC31A1 Protein, Human (Cell-Free, His-SUMO)	O15431 (M1-H190)	≥95%

Related Diseases

Diseases

Alias

Wilson Disease

Hepatolenticular Degeneration	WD
Wilson'S Disease	WND
Westphal-Strumpell Syndrome	Copper Storage Disease
Cerebral Pseudosclerosis	Westphal Pseudosclerosis
Hepatolenticular Degeneration Syndrome	Copper Retention
Hepatocerebral Degeneration	Kinnier-Wilson Disease
Neurohepatic Degeneration	Progressive Hepatolenticular Degeneration
Lenticular Degenerative Disease	Wilson'S Syndrome
Lenticular Syndrome

Combat Disorder

Combat Disorders

Combat Neurosis

Menkes Disease

Copper Transport Disease	Menkes Syndrome
MNK	Kinky Hair Disease
Steely Hair Disease	Menkes Kinky-Hair Syndrome
Mk	Steely Hair Syndrome
Menkea Syndrome	Md
Menkes Kinky Hair Syndrome	Hypocupremia, Congenital
Kinky Hair Syndrome	X-Linked Copper Deficiency
Menkes Kinky Hair Disease

Metal Metabolism Disorder

Metal Metabolism, Inborn Errors

Inborn Metal Metabolism Disorder

Deficiency Anemia

Anemia	Deficiency Anemias
Anaemia

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13188	SLC31A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SLC31A1	VGNC	VGNC:77455
Mus musculus	SLC31A1	MGD	MGI:1333843
Canis familiaris	SLC31A1	VGNC	VGNC:51761
Rattus norvegicus	SLC31A1	RGD	RGD:620059
Bos taurus	SLC31A1	VGNC	VGNC:34813
Felis catus	SLC31A1	VGNC	VGNC:102981
Others	SLC31A1	NCBI

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