Ddx3x - DEAD box helicase 3, X-linked Gene

Mus musculus

Also known as Ddx3; Fin14; D1Pas1-rs2

Gene ID: 13205 | Gene type: protein coding

About Ddx3x

Summary

Enables primary miRNA binding activity. Involved in positive regulation of NLRP3 inflammasome complex assembly and stress granule assembly. Acts upstream of or within with a negative effect on primary miRNA processing. Located in cytoplasmic stress granule. Part of NLRP3 inflammasome complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability. Orthologous to human DDX3X (DEAD-box helicase 3 X-linked). [provided by Alliance of Genome Resources, Apr 2022]

Ddx3x Products(1)

mRNA	Protein	Name
NM_010028.3	NP_034158.1	ATP-dependent RNA helicase DDX3X

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables primary miRNA binding	IDA IDA: Inferred from direct assay	28819115	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	18583960	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of NLRP3 inflammasome complex assembly	IDA IDA: Inferred from direct assay	31511697	MGI
acts upstream of or within negative effect primary miRNA processing	IDA IDA: Inferred from direct assay	28819115	MGI
acts upstream of or within negative effect primary miRNA processing	IMP IMP: Inferred from mutant phenotype	28819115	MGI
involved in stress granule assembly	IMP IMP: Inferred from mutant phenotype	31511697	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of NLRP3 inflammasome complex	IDA IDA: Inferred from direct assay	31511697	MGI
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	31511697	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ATP-dependent RNA helicase DDX3X

D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 3	D1Pas1-related sequence 2
DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 3	DEAD box RNA helicase DEAD3
DEAD box protein 3, X-chromosomal	DEAD-box protein 3 (DEAD-box RNA

Ddx3x Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Ddx3x	Q62167	TBK1	Homo sapiens	Q9UHD2	Peptide Array	18583960

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03646	DDX3X Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ddx3x	NCBI	NCBI:1654

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