CPEB2 - cytoplasmic polyadenylation element binding protein 2 Gene

Homo sapiens

Also known as CPEB-2; CPE-BP2; hCPEB-2

Gene ID: 132864 | Gene type: protein coding

About CPEB2

Cytogenetic location: 4p15.32 Genomic coordinates (GRCh38): 4:15,002,481-15,070,151 (from NCBI)

This gene has 8 transcripts (splice variants), 187 orthologues and 3 paralogues. Broad expression in testis (RPKM 12.0), skin (RPKM 7.9) and 24 other tissues.

Summary

The protein encoded by this gene is highly similar to cytoplasmic polyadenylation element binding protein (CPEB), an mRNA-binding protein that regulates cytoplasmic polyadenylation of mRNA as a trans factor in oogenesis and spermatogenesis. Studies of the similar gene in mice suggested a possible role of this protein in transcriptionally inactive haploid spermatids. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

CPEB2 Products(6)

mRNA	Protein	Name
NM_001177381.2	NP_001170852.1	cytoplasmic polyadenylation element-binding protein 2 isoform C
NM_001177382.2	NP_001170853.1	cytoplasmic polyadenylation element-binding protein 2 isoform D
NM_001177383.2	NP_001170854.1	cytoplasmic polyadenylation element-binding protein 2 isoform E
NM_001177384.2	NP_001170855.1	cytoplasmic polyadenylation element-binding protein 2 isoform F
NM_182485.3	NP_872291.2	cytoplasmic polyadenylation element-binding protein 2 isoform B
NM_182646.3	NP_872587.2	cytoplasmic polyadenylation element-binding protein 2 isoform A

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to hypoxia	IDA IDA: Inferred from direct assay	18752464	GOA
involved in cellular response to insulin stimulus	IDA IDA: Inferred from direct assay	18752464	GOA
involved in negative regulation of cytoplasmic translation	IMP IMP: Inferred from mutant phenotype	18752464	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	20639532	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20639532	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CPEB2 Protein Structure

RRM_1

0
100
200
300
400
500
589 a.a.

Protein Preferred Names

Protein Names

cytoplasmic polyadenylation element-binding protein 2

CPE-binding protein 2

Related Diseases

Diseases

Alias

Trichohepatoenteric Syndrome 1

Trichohepatoenteric Syndrome	Syndromic Diarrhea
Tricho-Hepato-Enteric Syndrome	Sd/The
Syndromic Diarrhea/Tricho-Hepato-Enteric Syndrome	THES1
Phenotypic Diarrhea	Thes
Phenotypic Diarrhea Of Infancy	Diarrhea, Syndromic
Diarrhea, Fatal Infantile, With Trichorrhexis Nodosa	Intractable Diarrhea With Phenotypic Anomalies
Syndromatic Diarrhea	Fatal Infantile Diarrhea With Trichorrhexis Nodosa

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03092	CPEB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CPEB2	VGNC	VGNC:53162
Macaca mulatta	CPEB2	VGNC	VGNC:100212
Bos taurus	CPEB2	VGNC	VGNC:107237
Rattus norvegicus	CPEB2	RGD	RGD:1307485
Mus musculus	CPEB2	MGD	MGI:2442640
Felis catus	CPEB2	VGNC	VGNC:78474

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