IL31RA - interleukin 31 receptor A Gene

Homo sapiens

Also known as CRL; GPL; CRL3; GLMR; GLM-R; PLCA2; hGLM-R; IL-31RA; PRO21384; zcytoR17

Gene ID: 133396 | Gene type: protein coding

About IL31RA

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:55,839,789-55,922,850 (from NCBI)

This gene has 13 transcripts (splice variants), 174 orthologues, 23 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

Summary

The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]

IL31RA Products(6)

mRNA	Protein	Name
NM_001242636.2	NP_001229565.1	interleukin-31 receptor subunit alpha isoform 2 precursor
NM_001242637.2	NP_001229566.1	interleukin-31 receptor subunit alpha isoform 3
NM_001242638.2	NP_001229567.1	interleukin-31 receptor subunit alpha isoform 4 precursor
NM_001242639.2	NP_001229568.1	interleukin-31 receptor subunit alpha isoform 5
NM_001297570.3	NP_001284499.1	interleukin-31 receptor subunit alpha isoform 6
NM_139017.7	NP_620586.3	interleukin-31 receptor subunit alpha isoform 1

IL31RA Protein Structure

IL6Ra-bind

fn3

0
200
400
600
764 a.a.

Protein Preferred Names

Protein Names

interleukin-31 receptor subunit alpha

IL-31 receptor subunit alpha

Recombinant IL31RA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75859	IL-31R alpha Protein, Human (HEK293, Fc)	Q8NI17-1/EAW54932.1 (A20-S516)	≥95%
HY-P75860	IL-31R alpha Protein, Human (HEK293, His)	Q8NI17-1/EAW54932.1 (A20-S516)	≥95%

Related Diseases

Diseases

Alias

Amyloidosis, Primary Localized Cutaneous, 2

PLCA2

Primary Localized Cutaneous Amyloidosis 2

Primary Cutaneous Amyloidosis

Plca	Primary Localized Cutaneous Amyloidosis
Familial Primary Localized Cutaneous Amyloidosis	Amyloidosis Ix
Lichen Amyloidosis Familial	Amyloidosis, Primary Cutaneous
Pca	Amyloidosis 9
Amyloidosis Familial Cutaneous Lichen	Fplca
Familial Lichen Amyloidosis

Dermatitis

Eczema	Skin Inflammation
Inflammatory Dermatosis

Lichen Amyloidosis

Amyloid Lichen	Lichen Amyloidosus
Amyloidosis, Primary Cutaneous

Macular Amyloidosis

Amyloidosis, Macular

Amyloidosis

Amyloid Disease	Amyloid
Amyloid Degeneration	Amyloidosis Nos
Amyloid Deposition	Amyloid Infiltration
Idiopathic Amyloidosis	Hyaloid Degeneration
Lardaceous Degeneration

Amyloidosis, Primary Localized Cutaneous, 3

Amyloidosis Cutis Dyschromica	PLCA3
Acd	Primary Localized Cutaneous Amyloidosis 3
Amyloidosis Cutis Dyschromia

Neurodermatitis

Contact Dermatitis

Contact Dermatitis/Eczema	Contact Eczema
Dermatitis Venenata	Dermatitis, Venenata
Dermatitis Contact	Dermatitis, Contact

Allergic Contact Dermatitis

Dermatitis, Allergic Contact	Contact Dermatitis, Allergic
Dermatitis Allergic Contact	Allergic Contact Eczema
Acd - [Allergic Contact Dermatitis]	Allergic Contact Dermatitis, Unspecified Cause
Allergic Dermatitis	Allergic Eczema
Allergy Dermatitis	Allergy Eczema
Allergic Contact Eczema Due To Clothing Or Footwear	Perfume Allergic Contact Dermatitis
Allergic Contact Dermatitis Due To Cosmetics	Allergic Contact Eczema Due To Cosmetics Or Fragrances
Allergic Contact Eczema Due To Dental Materials	Allergic Contact Eczema Due To Food Flavours Or Additives
Allergic Contact Eczema Due To Hairdressing Products	Allergic Contact Eczema Due To Metals Or Metal Salts
Allergic Contact Eczema Due To Proteins	Allergic Contact Eczema Due To Plastics Or Resin Systems
Allergic Contact Eczema Due To Preservatives Or Biocides	Allergic Contact Eczema Due To Rubber Chemicals
Rubber Dermatitis	Allergic Contact Eczema Due To Systemic Medicaments
Allergic Contact Eczema Due To Topical Medicaments	Allergic Contact Dermatitis Due To Drugs In Contact With Skin

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Congenital Central Hypoventilation Syndrome

Cchs	Haddad Syndrome
Ondine Curse	Ondine Syndrome
Congenital Central Hypoventilation	Congenital Central Alveolar Hypoventilation Syndrome
Congenital Failure Of Autonomic Control	Ondine'S Curse
Primary Alveolar Hypoventilation	Ondine-Hirschsprung Disease
Central Congenital Hypoventilation Syndrome	Congenital Ondine Curse
Idiopathic Congenital Central Alveolar Hypoventilation	Congenital Central Alveolar Hypoventilation-Hirschsprung Disease Syndrome
Ondine-Hirschsprung Syndrome

Noonan Syndrome 1

Noonan Syndrome	NS1
Male Turner Syndrome	Female Pseudo-Turner Syndrome
Turner Phenotype With Normal Karyotype	Noonan Syndrome With Pigmented Villonodular Synovitis
Turner'S Phenotype, Karyotype Normal	Familial Turner Syndrome
Noonan'S Syndrome	Noonan-Ehmke Syndrome
Ns	Pseudo-Ullrich-Turner Syndrome
Turner Syndrome In Female With X Chromosome	Turner-Like Syndrome
Ullrich-Noonan Syndrome	Noonan-Like/Multiple Giant Cell Lesion Syndrome
Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions	Pterygium Colli Syndrome
Noonan Syndrome, Type 1	Turner Syndrome, Male

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06755	IL31RA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990713	Nolavetbart		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IL31RA	MGD	MGI:2180511
Rattus norvegicus	IL31RA	RGD	RGD:1586478
Macaca mulatta	IL31RA	VGNC	VGNC:73624
Bos taurus	IL31RA	VGNC	VGNC:30154
Felis catus	IL31RA	VGNC	VGNC:62911
Canis familiaris	IL31RA	VGNC	VGNC:41981
Others	IL31RA	NCBI

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