1. Recombinant Proteins
  2. Cytokines and Growth Factors Receptor Proteins
  3. Interleukin & Receptors Cytokine Receptors
  4. IL-31 Receptor
  5. IL31RA
  6. IL-31R alpha Protein, Human (HEK293, His)

IL-31R alpha protein binds to IgM heavy and light chains and helps IgM assembly and secretion. It can act as a molecular chaperone or an oxidoreductase, exhibiting low oxidoreductase activity. IL-31R alpha Protein, Human (HEK293, His) is the recombinant human-derived IL-31R alpha protein, expressed by HEK293 , with C-His labeled tag.

For research use only. We do not sell to patients.

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Description

IL-31R alpha protein binds to IgM heavy and light chains and helps IgM assembly and secretion. It can act as a molecular chaperone or an oxidoreductase, exhibiting low oxidoreductase activity. IL-31R alpha Protein, Human (HEK293, His) is the recombinant human-derived IL-31R alpha protein, expressed by HEK293 , with C-His labeled tag.

Background

MZB1/PERP1 associates with immunoglobulin M (IgM) heavy and light chains, facilitating IgM assembly and secretion. It may function as a molecular chaperone or oxidoreductase, as it exhibits a low level of oxidoreductase activity. Additionally, isoform 2 may play a role in apoptosis regulation. MZB1/PERP1 contributes to the diversification of peripheral B-cell functions by modulating Ca(2+) stores, antibody secretion, and integrin activation. Furthermore, it acts as a hormone-regulated adipokine/pro-inflammatory cytokine implicated in chronic inflammation, affecting cellular expansion and attenuating insulin response in adipocytes, potentially playing a role in the onset of insulin resistance.

Species

Human

Source

HEK293

Tag

C-His

Accession

Q8NI17-1/EAW54932.1 (A20-S516)

Gene ID
Molecular Construction
N-term
IL-31Rα (A20-S516)
Accession # Q8NI17/EAW54932.1
His
C-term
Synonyms
Interleukin-31 receptor subunit alpha; IL-31R-alpha; IL-31RA; GLM-R; GLM-R; CRL3
Molecular Weight

Approximately 58.2 kDa

Purity

Greater than 85% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

IL-31R alpha Protein, Human (HEK293, His) Related Classifications

Help & FAQs
  • How should lyophilized recombinant proteins be reconstituted and stored?

    1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss. 2. Taking 10 μg as an example, first add 20 μL of reconstituted solution provided by MCE and use a pipette to gently resuspend the lyophilized protein until it is fully dissolved.. (For most proteins, the reconstitution solution we provide is sterile water. If a diluent other than water is required, it will be indicated in the product's Certificate of Analysis (COA).). 3. Add an additional 80 μL of buffer/culture medium containing carrier protein (either 0.1% BSA, 5% HSA, 10% FBS, or 5% trehalose), and then use a pipette to gently mix until uniform. The final concentration is should not be lower than 100 μg/mL. 4. Aliquot at least 20 μL per tube. 5. After aliquoting, store it frozen at a temperature ranging from -20ºC to -80ºC, and it can be preserved for 3 to 6 months.

  • How should solution-form recombinant proteins be stored?

    1. The product can be stored in its original form and diluted as needed upon use. 2. Alternatively, dilute with a buffer/culture medium containing a carrier protein (either 0.1% BSA, 5% HSA, 10% FBS, or 5% alginate), mix well by pipetting, and ensure that

  • Why is it necessary to add carrier proteins?

    Carrier proteins are commonly added to enhance the stability of recombinant proteins, preventing them from adhering to the walls of the container during freezing or thawing processes. Plastic tubes have a certain adsorptive capacity for proteins, which may lead to difficulty in separating the protein from the tube walls, resulting in a decrease in the actual concentration of the protein in the solution and thus affecting its activity. To minimize such losses, it is recommended to add a commonly used carrier protein solution prior to the long-term storage of recombinant protein products.

  • Carrier protein types and options?

    In cases where the carrier protein is not expected to influence the experimental outcomes, an appropriate carrier protein, such as 0.1% BSA (Bovine Serum Albumin), 5% HSA (Human Serum Albumin), 10% FBS (Fetal Bovine Serum), or 5% trehalose, can be incorpo

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Inquiry Information

Product Name:
IL-31R alpha Protein, Human (HEK293, His)
Cat. No.:
HY-P75860
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