Dkk1 - dickkopf WNT signaling pathway inhibitor 1 Gene

Mus musculus

Also known as mdkk-1

Gene ID: 13380 | Gene type: protein coding

About Dkk1

Summary

Predicted to enable co-receptor binding activity; low-density lipoprotein particle receptor binding activity; and receptor antagonist activity. Involved in several processes, including modulation of age-related behavioral decline; negative regulation of cellular component organization; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including Wnt signaling pathway involved in somitogenesis; embryonic morphogenesis; and negative regulation of signal transduction. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; embryo mesenchyme; eye; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in anodontia. Orthologous to human DKK1 (dickkopf Wnt signaling pathway inhibitor 1). [provided by Alliance of Genome Resources, Apr 2022]

Dkk1 Products(1)

mRNA	Protein	Name
NM_010051.3	NP_034181.2	dickkopf-related protein 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16126904	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of Wnt signaling pathway	IDA IDA: Inferred from direct assay	18462699	MGI
acts upstream of or within Wnt signaling pathway involved in somitogenesis	IGI IGI: Inferred from genetic interaction	18257070	MGI
acts upstream of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	18257070	MGI
acts upstream of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	18403408	MGI
acts upstream of or within cell morphogenesis	IMP IMP: Inferred from mutant phenotype	18403408	MGI
acts upstream of or within embryonic limb morphogenesis	IGI IGI: Inferred from genetic interaction	15242796	MGI
acts upstream of or within endoderm development	IMP IMP: Inferred from mutant phenotype	18403408	MGI
acts upstream of or within endoderm formation	IDA IDA: Inferred from direct assay	18462699	MGI
acts upstream of or within face morphogenesis	IMP IMP: Inferred from mutant phenotype	17699607	MGI
acts upstream of or within forebrain development	IGI IGI: Inferred from genetic interaction	17127040	MGI
acts upstream of or within hair follicle development	IDA IDA: Inferred from direct assay	16682203	MGI
acts upstream of or within head morphogenesis	IGI IGI: Inferred from genetic interaction	18403408	MGI
involved in heart induction	IDA IDA: Inferred from direct assay	18297060	MGI
involved in learning or memory	IDA IDA: Inferred from direct assay	23164821	MGI
involved in limb development	IMP IMP: Inferred from mutant phenotype	18505822	MGI
acts upstream of or within mesoderm formation	IDA IDA: Inferred from direct assay	18462699	MGI
involved in motor learning	IDA IDA: Inferred from direct assay	25318560	MGI
acts upstream of or within negative regulation of BMP signaling pathway	IDA IDA: Inferred from direct assay	19850029	MGI
acts upstream of or within negative regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	16126904	MGI
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	26206087	MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	17128274	MGI
involved in negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	17027228	MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	15143170	MGI
involved in negative regulation of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	16805831	MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	18403408	MGI
involved in negative regulation of neuron projection development	IDA IDA: Inferred from direct assay	29643768	MGI
involved in negative regulation of ossification	IMP IMP: Inferred from mutant phenotype	18505822	MGI
involved in negative regulation of presynapse assembly	IDA IDA: Inferred from direct assay	29643768	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17128274	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19850024	MGI
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	23164821	MGI
involved in positive regulation of midbrain dopaminergic neuron differentiation	IMP IMP: Inferred from mutant phenotype	21347250	MGI
acts upstream of or within regulation of Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	17127040	MGI
involved in regulation of synapse organization	IDA IDA: Inferred from direct assay	25318560	MGI
involved in regulation of synaptic transmission, glutamatergic	IDA IDA: Inferred from direct assay	25318560	MGI
acts upstream of or within response to retinoic acid	IDA IDA: Inferred from direct assay	17064353	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

dickkopf-related protein 1

dickkopf homolog 1	dickkopf-1
dickkopf-like protein 1	dkk-1

Recombinant Dkk1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7154	DKK-1 Protein, Mouse (CHO)	O54908 (S30-H272)	≥95%
HY-P72969	DKK-1 Protein, Mouse (HEK293, His)	O54908 (T32-H272)	≥95%

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14930A	Mirodenafil dihydrochloride		99.85%	Unkown
HY-14930	Mirodenafil		99.70%	Unkown

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-11035	WAY-262611	Agonist	99.51%	Unkown
HY-D0961	Gallocyanine chloride	Inhibitor	92.00%	Unkown
HY-162970	XD23		/	Unkown
HY-RS03787	DKK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dkk1	NCBI	NCBI:22943
Macaca fascicularis	Dkk1	NCBI	NCBI:102123735
Rattus norvegicus	Dkk1	NCBI	NCBI:293897
Macaca mulatta	Dkk1	NCBI	NCBI:702997

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