2. Gene
  3. DKK1 - Dkk1 dickkopf WNT signaling pathway inhibitor 1 Gene

DKK1 - Dkk1 dickkopf WNT signaling pathway inhibitor 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 293897 | Gene type: protein coding

About DKK1

Summary

Predicted to enable co-receptor binding activity; low-density lipoprotein particle receptor binding activity; and receptor antagonist activity. Involved in negative regulation of ossification and positive regulation of neuron death. Located in extracellular space. Used to study visual epilepsy. Human ortholog(s) of this gene implicated in anodontia. Orthologous to human DKK1 (dickkopf Wnt signaling pathway inhibitor 1). [provided by Alliance of Genome Resources, Apr 2022]

DKK1 Products(1)

mRNA Protein Name
NM_001106350.1 NP_001099820.1 dickkopf-related protein 1 precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of ossification IMP
IMP: Inferred from mutant phenotype
21773994 RGD
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
22009597 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dickkopf-related protein 1

dickkopf 1 homolog

dickkopf homolog 1

dickkopf-like protein 1

Recombinant DKK1 Proteins

Cat. No. Product Name Accession Purity
HY-P73305 DKK-1 Protein, Rat (HEK293, His, solution) A6I0Z0/NP_001099820.1 (T32-H270) ≥95%
HY-P73305A DKK-1 Protein, Rat (HEK293, C-His) A6I0Z0/NP_001099820.1 (T32-H270) ≥95%

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14930A Mirodenafil dihydrochloride 99.85% Unkown
HY-14930 Mirodenafil 99.70% Unkown
Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-11035 WAY-262611 99.51% Unkown
HY-D0961 Gallocyanine chloride Inhibitor 92.00% Unkown
HY-162970 XD23 Activator / Unkown
HY-RS03787 DKK1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens DKK1 NCBI NCBI:22943
Macaca fascicularis DKK1 NCBI NCBI:102123735
Mus musculus DKK1 NCBI NCBI:13380
Macaca mulatta DKK1 NCBI NCBI:702997