LSM11 - LSM11, U7 small nuclear RNA associated Gene

Homo sapiens

Also known as AGS8

Gene ID: 134353 | Gene type: protein coding

About LSM11

Cytogenetic location: 5q33.3 Genomic coordinates (GRCh38): 5:157,743,712-157,760,709 (from NCBI)

This gene has 1 transcript (splice variant), 193 orthologues and is associated with 1 phenotype. Ubiquitous expression in brain (RPKM 3.6), testis (RPKM 3.3) and 25 other tissues.

Summary

Enables U7 snRNA binding activity. Involved in positive regulation of G1/S transition of mitotic cell cycle. Located in nuclear body. Part of U7 snRNP and Telomerase holoenzyme complex. Implicated in Aicardi-Goutieres syndrome. [provided by Alliance of Genome Resources, Apr 2022]

LSM11 Products(1)

mRNA	Protein	Name
NM_173491.4	NP_775762.1	U7 snRNA-associated Sm-like protein LSm11

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables U7 snRNA binding	IDA IDA: Inferred from direct assay	12975319	GOA
enables U7 snRNA binding	IPI IPI: Inferred from physical interaction	18082603	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12975319	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA 3'-end processing by stem-loop binding and cleavage	IMP IMP: Inferred from mutant phenotype	33230297	GOA
involved in positive regulation of G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	16914750	GOA
involved in regulation of chromatin organization	IMP IMP: Inferred from mutant phenotype	33230297	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of U7 snRNP	IDA IDA: Inferred from direct assay	11574479	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12975319	GOA
part of telomerase holoenzyme complex	IDA IDA: Inferred from direct assay	18082603	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LSM11 Protein Structure

LSM

0
100
200
300
360 a.a.

Protein Preferred Names

Protein Names

U7 snRNA-associated Sm-like protein LSm11

LSM11 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LSM11	P83369	RAB19	Homo sapiens	A4D1S5	Y2H Array	32296183
Intra	LSM11	P83369	RAB19	Homo sapiens	A4D1S5	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Aicardi-Goutieres Syndrome 8

AGS8

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Aicardi-Goutières Syndrome	Encephalopathy With Basal Ganglia Calcification
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

Cerebrooculofacioskeletal Syndrome 2

COFS2	Cerebro-Oculo-Facio-Skeletal Syndrome 2
Cofs Syndrome

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07854	LSM11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LSM11	VGNC	VGNC:102246
Mus musculus	LSM11	MGD	MGI:1919540
Bos taurus	LSM11	VGNC	VGNC:54446
Rattus norvegicus	LSM11	RGD	RGD:1565523
Macaca mulatta	LSM11	VGNC	VGNC:110453

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