Drd3 - dopamine receptor D3 Gene

Mus musculus

Also known as D3R

Gene ID: 13490 | Gene type: protein coding

About Drd3

Chromosome 16: 43,574,389-43,643,295 forward strand.GRCm39:CM001009.3

This gene has 2 transcripts (splice variants), 206 orthologues, 32 paralogues and is associated with 39 phenotypes. Low expression observed in reference dataset.

Summary

Enables dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in behavioral response to cocaine and regulation of neurotransmitter uptake. Acts upstream of or within several processes, including regulation of blood pressure; regulation of Dopamine Receptor signaling pathway; and response to alkaloid. Located in plasma membrane. Is active in dopaminergic synapse. Is expressed in several structures, including brain; exocrine gland; genitourinary system; gut; and sensory organ. Used to study restless legs syndrome. Human ortholog(s) of this gene implicated in Parkinson's disease; essential tremor; essential tremor 1; and schizophrenia. Orthologous to human DRD3 (Dopamine Receptor D3). [provided by Alliance of Genome Resources, Apr 2022]

Drd3 Products(1)

mRNA	Protein	Name
NM_007877.2	NP_031903.1	D(3) dopamine receptor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go	IDA IDA: Inferred from direct assay	7566118	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16386234	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of G protein-coupled dopamine receptor signaling pathway	IGI IGI: Inferred from genetic interaction	12097513	MGI
acts upstream of G protein-coupled dopamine receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15016423	MGI
acts upstream of or within adenylate cyclase-activating dopamine receptor signaling pathway	IDA IDA: Inferred from direct assay	16386234	MGI
involved in behavioral response to cocaine	IMP IMP: Inferred from mutant phenotype	10432116	MGI
acts upstream of or within circadian regulation of gene expression	IMP IMP: Inferred from mutant phenotype	15878801	MGI
acts upstream of or within locomotory behavior	IGI IGI: Inferred from genetic interaction	9354330	MGI
NOT acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	10221759	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	8700864	MGI
acts upstream of or within musculoskeletal movement, spinal reflex action	IMP IMP: Inferred from mutant phenotype	15601940	MGI
acts upstream of or within negative regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	9691085	MGI
acts upstream of or within negative regulation of dopamine receptor signaling pathway	IGI IGI: Inferred from genetic interaction	12097513	MGI
acts upstream of or within negative regulation of oligodendrocyte differentiation	IDA IDA: Inferred from direct assay	9651217	MGI
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	17251429	MGI
acts upstream of oligodendrocyte differentiation	IDA IDA: Inferred from direct assay	9651217	MGI
acts upstream of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	17251429	MGI
acts upstream of or within positive regulation of dopamine receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15016423	MGI
acts upstream of or within regulation of blood volume by renin-angiotensin	IGI IGI: Inferred from genetic interaction	9691085	MGI
acts upstream of or within regulation of blood volume by renin-angiotensin	IMP IMP: Inferred from mutant phenotype	9691085	MGI
acts upstream of or within regulation of dopamine secretion	IMP IMP: Inferred from mutant phenotype	9482807	MGI
acts upstream of or within regulation of lipid metabolic process	IMP IMP: Inferred from mutant phenotype	15084447	MGI
acts upstream of or within regulation of multicellular organism growth	IMP IMP: Inferred from mutant phenotype	15084447	MGI
involved in regulation of neurotransmitter uptake	EXP EXP: Inferred from Experiment	27393374	MGI
involved in regulation of neurotransmitter uptake	IDA IDA: Inferred from direct assay	27393374	MGI
acts upstream of or within response to amphetamine	IGI IGI: Inferred from genetic interaction	12097513	MGI
acts upstream of or within response to cocaine	IMP IMP: Inferred from mutant phenotype	10943692	MGI
NOT acts upstream of or within response to ethanol	IMP IMP: Inferred from mutant phenotype	12873629	MGI
acts upstream of or within response to ethanol	IMP IMP: Inferred from mutant phenotype	11988344	MGI
acts upstream of or within response to morphine	IMP IMP: Inferred from mutant phenotype	12574430	MGI
acts upstream of or within visual learning	IMP IMP: Inferred from mutant phenotype	12097513	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in dopaminergic synapse	EXP EXP: Inferred from Experiment	27393374	MGI
is active in dopaminergic synapse	IDA IDA: Inferred from direct assay	27393374	MGI
located in membrane	IDA IDA: Inferred from direct assay	9651217	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	9651217	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Drd3 Protein Structure

7tmA_D3_dopamine_R

0
100
200
300
400
446 a.a.

Protein Preferred Names

Protein Names

D(3) dopamine receptor

dopamine D3 receptor

dopamine receptor 3

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-19654	GSK598809	Antagonist	99.74%	Phase 2

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19654C	(-)-GSK598809 hydrochloride	Antagonist	99.64%	Unkown
HY-19654B	(-)-GSK598809	Antagonist	/	Unkown
HY-RS04000	DRD3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04001	Drd3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04002	Drd3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Drd3	NCBI	NCBI:1814

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