S1pr3 - sphingosine-1-phosphate receptor 3 Gene

Mus musculus

Also known as Edg3; Lpb3; S1p3

Gene ID: 13610 | Gene type: protein coding

About S1pr3

Chromosome 13: 51,562,675-51,576,833 forward strand.GRCm39:CM001006.3

This gene has 1 transcript (splice variant), 194 orthologues, 18 paralogues and is associated with 19 phenotypes. Broad expression in limb E14.5 (RPKM 3.), lung adult (RPKM 2.8) and 19 other tissues.

Summary

This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for the lysophospholipid sphingosine 1-phosphate. The gene product functions in endothelial cells and is involved in vascular and heart development. The gene product mediates HDL and HDL-associated lysophospholipid-induced vasorelaxation, and it coordinates with Other lysophospholipid receptors in the process of angiogenesis. [provided by RefSeq, Jan 2010]

S1pr3 Products(1)

mRNA	Protein	Name
NM_010101.4	NP_034231.1	sphingosine 1-phosphate receptor 3

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Notch signaling pathway	IDA IDA: Inferred from direct assay	23117660	MGI
acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	11443127	MGI
acts upstream of or within cytokine production	IMP IMP: Inferred from mutant phenotype	18305483	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	18305483	MGI
acts upstream of or within regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	18305483	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in presynapse	IDA IDA: Inferred from direct assay	35781853	MGI
is active in presynapse	IEP IEP: Inferred from expression pattern	35781853	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S1pr3 Protein Structure

7tmA_S1PR3_Edg3

0
100
200
300
378 a.a.

Protein Preferred Names

Protein Names

sphingosine 1-phosphate receptor 3

S1P receptor Edg-3	S1p receptor 3
endothelial differentiation G-protein coupled receptor 3	endothelial differentiation sphingolipid G-protein-coupled receptor 3
lysophospholipid receptor B3	sphingosine 1-phosphate receptor Edg-3

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12355	Siponimod	Agonist	99.95%	Yes
HY-10569	Ponesimod	Agonist	99.81%	Yes
HY-12355A	Siponimod hemifumarate	Agonist	/	Unkown

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-119401	CAY10444	Antagonist	≥98.0%	Unkown
HY-111253	CYM-5478	Agonist	99.90%	Unkown
HY-113934	L-threo Lysosphingomyelin (d18:1)	Agonist	≥98.0%	Unkown
HY-108492	TC-SP 14	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	S1pr3	NCBI	NCBI:1903

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