Siponimod hemifumarate (Synonyms: BAF-312 hemifumarate)

Cat. No.: HY-12355A: FAQs
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Siponimod (BAF-312) hemifumarate is a potent and selective sphingosine-1-phosphate (S1P) receptor modulator. Siponimod hemifumarate is selective for S1P1 and S1P5 receptors over S1P2, S1P3, and S1P4 (EC₅₀s of 0.39, 0.98, >10000, >1000, and 750 nM, respectively). Siponimod hemifumarate can be used for multiple sclerosis (MS) research.

For research use only. We do not sell to patients.

Siponimod hemifumarate Chemical Structure

CAS No. : 1234627-85-0

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Other In-stock Forms of Siponimod hemifumarate:

Siponimod

Other Forms of Siponimod hemifumarate:

Siponimod In-stock
Siponimod-d₁₁ Get quote

8 Publications Citing Use of MCE Siponimod hemifumarate

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•Related Small Molecules:

•Related Proteins:

View All LPL Receptor Isoform Specific Products:

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LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

S1PR1

0.39 nM (EC₅₀)

S1PR5

0.98 nM (EC₅₀)

S1PR4

750 nM (EC₅₀)

S1PR3

>1000 nM (EC₅₀)

S1PR2

>10000 nM (EC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	0.0004 μM Compound: 32, BAF312, Siponimod	Agonist activity at human S1P1 receptor transfected in CHO cells incubated for 10 to 15 mins prior to GTPgamma35S addition measured after 120 mins by GTPgamma35S binding assay Agonist activity at human S1P1 receptor transfected in CHO cells incubated for 10 to 15 mins prior to GTPgamma35S addition measured after 120 mins by GTPgamma35S binding assay	[PMID: 24900670]
CHO	EC₅₀	0.98 nM Compound: 3, BAF312	Agonist activity at human S1P5 receptor expressed in CHO cells by [35S]GTPgammaS binding assay Agonist activity at human S1P5 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	[PMID: 24125884]
CHO	EC₅₀	5 μM Compound: 32, BAF312, Siponimod	Agonist activity at human S1P3 receptor transfected in CHO cells incubated for 10 to 15 mins prior to GTPgamma35S addition measured after 120 mins by GTPgamma35S binding assay Agonist activity at human S1P3 receptor transfected in CHO cells incubated for 10 to 15 mins prior to GTPgamma35S addition measured after 120 mins by GTPgamma35S binding assay	[PMID: 24900670]
CHO	EC₅₀	750 nM Compound: 3, BAF312	Agonist activity at human S1P4 receptor expressed in CHO cells by [35S]GTPgammaS binding assay Agonist activity at human S1P4 receptor expressed in CHO cells by [35S]GTPgammaS binding assay	[PMID: 24125884]

Clinical Trial

Molecular Weight

574.63

Formula

C₂₉H₃₅F₃N₂O₃.1/2C₄H₄O₄

CAS No.

1234627-85-0

SMILES

O=C(C1CN(CC2=CC=C(/C(C)=N/OCC3=CC=C(C4CCCCC4)C(C(F)(F)F)=C3)C=C2CC)C1)O.OC(/C=C/C(O)=O)=O.[1/2]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Pan S, et al. Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator. ACS Med Chem Lett. 2013 Jan 4;4(3):333-7. [Content Brief]

[2]. McGinley M, et al. Prospects of siponimod in secondary progressive multiple sclerosis. Ther Adv Neurol Disord. 2018 Jul 17;11:1756286418788013. [Content Brief]

[3]. Behrangi N, et al. Mechanism of Siponimod: Anti-Inflammatory and Neuroprotective Mode of Action. Cells. 2019 Jan 7;8(1):24. [Content Brief]

Siponimod hemifumarate Related Classifications

Neurological Disease Inflammation/Immunology

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

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