S1pr4 - sphingosine-1-phosphate receptor 4 Gene

Mus musculus

Also known as Edg6; Lpc1; S1p4

Gene ID: 13611 | Gene type: protein coding

About S1pr4

Chromosome 10: 81,333,581-81,335,966 reverse strand.GRCm39:CM001003.3

This gene has 1 transcript (splice variant), 176 orthologues, 18 paralogues and is associated with 4 phenotypes.

Summary

This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for the lysophospholipid sphingosine 1-phosphate. The encoded protein is one of the predominant sphingosine 1-phosphate G-protein coupled receptors expressed in T cells, and it plays a role in suppression of T cell proliferation, generation of cytokines, and potentially Other aspects of immune activation. [provided by RefSeq, Feb 2010]

S1pr4 Products(1)

mRNA	Protein	Name
NM_010102.2	NP_034232.1	sphingosine 1-phosphate receptor 4

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	11443127	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in presynapse	IDA IDA: Inferred from direct assay	35781853	MGI
is active in presynapse	IEP IEP: Inferred from expression pattern	35781853	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S1pr4 Protein Structure

7tm_GPCRs

0
100
200
300
386 a.a.

Protein Preferred Names

Protein Names

sphingosine 1-phosphate receptor 4

S1P receptor Edg-6	S1p receptor 4
endothelial differentiation G-protein-coupled receptor 6	lysophospholipid receptor C1
sphingosine 1-phosphate receptor Edg-6

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12355	Siponimod	Agonist	99.95%	Yes
HY-10569	Ponesimod	Agonist	99.81%	Yes
HY-12355A	Siponimod hemifumarate	Agonist	/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-17606	Cenerimod	Agonist	99.43%	Phase 3

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136462	CYM50358	Antagonist	98.04%	Unkown
HY-116146	CYM50179	Agonist	96.06%	Unkown
HY-111253	CYM-5478	Agonist	99.90%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	S1pr4	NCBI	NCBI:8698

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