S1PR4 - sphingosine-1-phosphate receptor 4 Gene

Homo sapiens

Also known as EDG6; LPC1; S1P4; SLP4

Gene ID: 8698 | Gene type: protein coding

About S1PR4

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:3,178,769-3,180,332 (from NCBI)

This gene has 2 transcripts (splice variants), 176 orthologues and 18 paralogues.

Summary

This gene is a member of the endothelial differentiation, G-protein-coupled (EDG)) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue. [provided by RefSeq, Jul 2008]

S1PR4 Products(1)

mRNA	Protein	Name
NM_003775.4	NP_003766.1	sphingosine 1-phosphate receptor 4 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S1PR4 Protein Structure

7tm_1

0
100
200
300
384 a.a.

Protein Preferred Names

Protein Names

sphingosine 1-phosphate receptor 4

S1P receptor 4	S1P receptor Edg-6
endothelial differentiation G-protein coupled receptor 6	endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 6
sphingosine 1-phosphate receptor Edg-6

S1PR4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	S1PR4	O95977	GEMIN4	Homo sapiens	P57678	Y2H Prey Pooling	32296183
Intra	S1PR4	O95977	GEMIN4	Homo sapiens	P57678	Validated Y2H	32296183
Intra	S1PR4	O95977	GEMIN4	Homo sapiens	P57678	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

S1PR4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80967	S1PR4 Antibody	WB, IHC-P	Rat

Related Diseases

Diseases

Alias

Dermatitis, Atopic, 7

ATOD7	Dermatitis, Atopic, Susceptibility To, 7
Atopic Dermatitis 7	Dermatitis, Atopic 7

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12355	Siponimod	Agonist	99.95%	Yes
HY-10569	Ponesimod	Agonist	99.81%	Yes
HY-12355A	Siponimod hemifumarate	Agonist	/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-17606	Cenerimod	Agonist	99.43%	Phase 3

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136462	CYM50358	Antagonist	98.04%	Unkown
HY-116146	CYM50179	Agonist	96.06%	Unkown
HY-111253	CYM-5478	Agonist	99.90%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	S1PR4	VGNC	VGNC:110551
Rattus norvegicus	S1PR4	RGD	RGD:1304801
Felis catus	S1PR4	VGNC	VGNC:64848
Mus musculus	S1PR4	MGD	MGI:1333809
Bos taurus	S1PR4	VGNC	VGNC:34255

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