2. Gene
  3. CPM - carboxypeptidase M Gene

CPM - carboxypeptidase M Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 1368 | Gene type: protein coding

About CPM

Cytogenetic location: 12q15 Genomic coordinates (GRCh38): 12:68,842,197-68,963,469 (from NCBI)

This gene has 13 transcripts (splice variants), 198 orthologues and 7 paralogues. Broad expression in fat (RPKM 56.0), lung (RPKM 21.3) and 19 other tissues.

Summary

The protein encoded by this gene is a membrane-bound arginine/lysine Carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

CPM Products(21)

mRNA Protein Name
NM_001005502.3 NP_001005502.1 carboxypeptidase M isoform b precursor
NM_001413387.1 NP_001400316.1 carboxypeptidase M isoform a precursor
NM_001413388.1 NP_001400317.1 carboxypeptidase M isoform b precursor
NM_001413389.1 NP_001400318.1 carboxypeptidase M isoform b precursor
NM_001413390.1 NP_001400319.1 carboxypeptidase M isoform b precursor
NM_001413391.1 NP_001400320.1 carboxypeptidase M isoform b precursor
NM_001413392.1 NP_001400321.1 carboxypeptidase M isoform c
NM_001413393.1 NP_001400322.1 carboxypeptidase M isoform d precursor
NM_001413394.1 NP_001400323.1 carboxypeptidase M isoform d precursor
NM_001413395.1 NP_001400324.1 carboxypeptidase M isoform e
NM_001413396.1 NP_001400325.1 carboxypeptidase M isoform e
NM_001413397.1 NP_001400326.1 carboxypeptidase M isoform f
NM_001413398.1 NP_001400327.1 carboxypeptidase M isoform f
NM_001413399.1 NP_001400328.1 carboxypeptidase M isoform f
NM_001413400.1 NP_001400329.1 carboxypeptidase M isoform f
NM_001413401.1 NP_001400330.1 carboxypeptidase M isoform f
NM_001413402.1 NP_001400331.1 carboxypeptidase M isoform g precursor
NM_001413403.1 NP_001400332.1 carboxypeptidase M isoform h
NM_001413404.1 NP_001400333.1 carboxypeptidase M isoform h
NM_001874.5 NP_001865.1 carboxypeptidase M isoform b precursor
NM_198320.5 NP_938079.1 carboxypeptidase M isoform b precursor

CPM Protein Structure

Peptidase_M14

Peptidase_M14: Zinc carboxypeptidase (28 - 302)

CarboxypepD_reg

CarboxypepD_reg: Carboxypeptidase regulatory-like domain (315 - 381)

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  • 443 a.a.
Protein Preferred Names Protein Names

carboxypeptidase M

renal carboxypeptidase

Recombinant CPM Proteins

Cat. No. Product Name Accession Purity
HY-P7737 Carboxypeptidase M/CPM Protein, Human (HEK293, His) P14384 (L18-D421) ≥95%

Related Diseases

Diseases Alias
Lateral Medullary Syndrome

Posterior Inferior Cerebellar Artery Syndrome

Wallenberg Syndrome

Vertebral Artery Syndrome

Wallenberg'S Syndrome

Pica Syndrome
Esophagus Sarcoma

Esophageal Sarcoma
Breast Liposarcoma

Liposarcoma Of The Breast
Liposarcoma

Lipomatous Cancer
Pneumoconiosis

Pneumoconioses

Silicosis Nos

Complicated Silicosis

Fibrosis Of Lung With Silicosis

Nodular Silicosis

Pneumoconiosis Due To Silica

Silicotic Fibrosis Of Lung

Simple Silicosis

Silicatosis

Silicotic Lung Fibrosis

Pneumoconiosis Due To Talc

Pulmonary Talcosis

Talc Lung Disease

Talc Pneumoconiosis

Talc Workers' Pneumoconiosis

Talcosis

Fibrosis Of Lung Due To Talc

Asbestos Pneumoconiosis

Amianthosis

Asbestosis

Lung Fibrosis With Asbestosis

Pulmonary Asbestosis
Brain Stem Infarction

Brain Stem Infarctions

Brainstem Infarction
Well-Differentiated Liposarcoma

Atypical Lipomatous Tumor

Atypical Lipoma

Alt

Wdls

Liposarcoma, Well Differentiated

Pleomorphic Lipoma
Hereditary Angioedema

Hereditary Angioneurotic Edema

Hereditary Angioedema Type 1

Hane

Angioedema, Hereditary

Hae

Angioedemas, Hereditary

Deficiency Of C1 Esterase Inhibitor

C1 Esterase Inhibitor Deficiency

C1 Inhibitor Deficiency

Familial Angioneurotic Edema

Hereditary Bradykinine-Induced Angioedema

Hereditary Non Histamine-Induced Angioedema

Hae 1

Hae-I

Hereditary Angioneurotic Edema Type 1

Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor

Hereditary Angioedema Types I And Ii

Hereditary Angioneurotic Oedema

Familial Angioedema

Hae - [Hereditary Angioneurotic Oedema]

Bannister Disease, Hereditary

Quincke Disease Or Oedema

Hereditary Quincke Oedema
Cleft Palate, Isolated

Cleft Palate

Isolated Cleft Palate

CPI

Cp

Palatoschisis

Cleft Palate Isolated

Uranostaphyloschisis

Congenital Fissure Of Palate

Cleft Of Secondary Palate
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13010 Laquinimod 99.96% Yes
Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-D0069 CPM ≥99.0% Phase 4
Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03100 CPM Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-13010S Laquinimod-d5 Inhibitor 98.25% Unkown
HY-W062904 Laquinimod sodium Inhibitor / Unkown
HY-P10057 cpm-1285 Inducer / Unkown
HY-P10058 cpm-1285m / Unkown
HY-D2376 BH-Vis / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CPM VGNC VGNC:54521
Bos taurus CPM VGNC VGNC:27655
Mus musculus CPM MGD MGI:1917824
Rattus norvegicus CPM RGD RGD:1310532
Macaca mulatta CPM VGNC VGNC:71461
Felis catus CPM VGNC VGNC:61126
Others CPM NCBI