CR1L - complement C3b/C4b receptor 1 like Gene

Homo sapiens

Gene ID: 1379 | Gene type: protein coding

About CR1L

Cytogenetic location: 1q32.2 Genomic coordinates (GRCh38): 1:207,645,133-207,723,703 (from NCBI)

This gene has 5 transcripts (splice variants), 21 orthologues and 39 paralogues. Biased expression in bone marrow (RPKM 3.2), appendix (RPKM 1.6) and 5 other tissues.

Summary

Acts upstream of or within regulation of complement activation and regulation of complement-dependent cytotoxicity. Part of receptor complex. [provided by Alliance of Genome Resources, Apr 2022]

CR1L Products(1)

mRNA	Protein	Name
NM_175710.2	NP_783641.1	complement component receptor 1-like protein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within regulation of complement activation	IDA IDA: Inferred from direct assay	25284781	GOA
acts upstream of or within regulation of complement-dependent cytotoxicity	IDA IDA: Inferred from direct assay	25284781	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CR1L Protein Structure

Sushi

0
100
200
300
400
500
569 a.a.

Protein Preferred Names

Protein Names

complement component receptor 1-like protein

complement C4b-binding protein CR-1-like protein

CR1L Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CR1L	Q2VPA4	DDHD1	Homo sapiens	Q8NEL9-2	Validated Y2H	32296183
Intra	CR1L	Q2VPA4	DDHD1	Homo sapiens	Q8NEL9-2	Y2H Prey Pooling	32296183
Intra	CR1L	Q2VPA4	DDHD1	Homo sapiens	Q8NEL9-2	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Complement Component Receptor 1

Cortisone Reductase Deficiency

11-Alpha Beta-Hydroxysteroid Dehydrogenase Type I Deficiency Of	Cortrd
Hsd 11b1 Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03132	CR1L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CR1L	RGD	RGD:2399
Mus musculus	CR1L	MGD	MGI:88513

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