2. Gene
  3. En2 - engrailed 2 Gene

En2 - engrailed 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as En-2; mo-En-2

Gene ID: 13799 | Gene type: protein coding

About En2

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in embryonic brain development and negative regulation of neuron apoptotic process. Acts upstream of or within nervous system development and positive regulation of transcription by RNA polymerase II. Predicted to be located in fibrillar center; membrane; and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; embryo ectoderm; genitourinary system; gut; and limb bud. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human EN2 (engrailed homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

En2 Products(2)

mRNA Protein Name
NM_001395060.1 NP_001381989.1 homeobox protein engrailed-2 isoform 2
NM_010134.4 NP_034264.1 homeobox protein engrailed-2 isoform 1
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within dopaminergic neuron differentiation IGI
IGI: Inferred from genetic interaction
15175251 MGI
involved in embryonic brain development IGI
IGI: Inferred from genetic interaction
7624797 MGI
acts upstream of or within hindbrain development IGI
IGI: Inferred from genetic interaction
15607945 MGI
acts upstream of or within midbrain development IGI
IGI: Inferred from genetic interaction
15175251 MGI
involved in negative regulation of neuron apoptotic process IGI
IGI: Inferred from genetic interaction
15175251 MGI
acts upstream of or within neuron development IGI
IGI: Inferred from genetic interaction
11312297 MGI
acts upstream of or within neuron differentiation IGI
IGI: Inferred from genetic interaction
15340832 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9102311 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein engrailed-2

homeobox protein en-2

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04366 EN2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-402815 (E)-4-(Naphthalen-2-yl)but-3-en-2-one / Unkown
HY-N1024 11R,12-Dihydroxyspirovetiv-1(10)-en-2-one / Unkown
HY-N1024A 11S,12-Dihydroxyspirovetiv-1(10)-en-2-one / Unkown
HY-N1759 3,11,12-Trihydroxyspirovetiv-1(10)-en-2-one / Unkown
HY-N9018 4-(6-Methyl-4-oxohept-5-en-2-yl)cyclohex-2-en-1-one / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens En2 NCBI NCBI:2020
Macaca fascicularis En2 NCBI NCBI:102116747