Erbb4 - erb-b2 receptor tyrosine kinase 4 Gene

Mus musculus

Also known as Her4; c-erbB-4

Gene ID: 13869 | Gene type: protein coding

About Erbb4

Chromosome 1: 68,071,345-69,147,218 reverse strand.GRCm39:CM000994.3

This gene has 5 transcripts (splice variants), 227 orthologues, 53 paralogues and is associated with 18 phenotypes. Biased expression in CNS E18 (RPKM 2.3), frontal lobe adult (RPKM 2.1) and 8 other tissues.

Summary

Enables protein tyrosine kinase activity. Involved in several processes, including mammary gland development; nervous system development; and positive regulation of nitrogen compound metabolic process. Acts upstream of or within several processes, including cellular response to epidermal growth factor stimulus; peptidyl-tyrosine autophosphorylation; and regulation of apoptotic process. Located in GABA-ergic synapse and glutamatergic synapse. Is integral component of postsynaptic density membrane. Is integral component of presynaptic membrane. Is expressed in several structures, including brain; early conceptus; embryo ectoderm; heart; and mammary gland primordium. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 19; colorectal cancer; esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human ERBB4 (erb-b2 receptor tyrosine kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Erbb4 Products(1)

mRNA	Protein	Name
NM_010154.2	NP_034284.1	receptor tyrosine-protein kinase erbB-4 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GABA receptor binding	IDA IDA: Inferred from direct assay	24218551	MGI
enables epidermal growth factor receptor activity	IGI IGI: Inferred from genetic interaction	12621152	MGI
enables neuregulin receptor activity	IDA IDA: Inferred from direct assay	8702723	MGI
enables neuregulin receptor activity	IMP IMP: Inferred from mutant phenotype	19632177	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16061658	MGI
enables transmembrane receptor protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	9168114	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERBB2-ERBB4 signaling pathway	IDA IDA: Inferred from direct assay	8702723	MGI
involved in ERBB2-ERBB4 signaling pathway	IGI IGI: Inferred from genetic interaction	12621152	MGI
involved in ERBB4 signaling pathway	IMP IMP: Inferred from mutant phenotype	16446434	MGI
involved in ERBB4-ERBB4 signaling pathway	IDA IDA: Inferred from direct assay	8702723	MGI
involved in cardiac muscle tissue regeneration	IMP IMP: Inferred from mutant phenotype	19632177	MGI
acts upstream of or within cell fate commitment	IDA IDA: Inferred from direct assay	12399441	MGI
involved in cell surface receptor signaling pathway	IDA IDA: Inferred from direct assay	24218551	MGI
involved in cell surface receptor signaling pathway via JAK-STAT	IMP IMP: Inferred from mutant phenotype	10508857	MGI
acts upstream of or within cellular response to epidermal growth factor stimulus	IDA IDA: Inferred from direct assay	8702723	MGI
involved in central nervous system morphogenesis	IMP IMP: Inferred from mutant phenotype	10655590	MGI
involved in embryonic pattern specification	IMP IMP: Inferred from mutant phenotype	10655590	MGI
acts upstream of or within establishment of planar polarity involved in nephron morphogenesis	IMP IMP: Inferred from mutant phenotype	22076439	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	7477376	MGI
involved in lactation	IMP IMP: Inferred from mutant phenotype	10508857	MGI
involved in mammary gland alveolus development	IMP IMP: Inferred from mutant phenotype	10508857	MGI
involved in mammary gland epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	16837552	MGI
acts upstream of or within nervous system development	IMP IMP: Inferred from mutant phenotype	7477376	MGI
involved in neural crest cell migration	IMP IMP: Inferred from mutant phenotype	10655590	MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	22184199	MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane	IMP IMP: Inferred from mutant phenotype	22184199	MGI
involved in olfactory bulb interneuron differentiation	IMP IMP: Inferred from mutant phenotype	15543145	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	16837552	MGI
involved in positive regulation of cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	19632177	MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI IGI: Inferred from genetic interaction	18458158	MGI
acts upstream of or within positive regulation of protein localization to cell surface	IGI IGI: Inferred from genetic interaction	18458158	MGI
involved in positive regulation of receptor signaling pathway via JAK-STAT	IMP IMP: Inferred from mutant phenotype	16837552	MGI
involved in positive regulation of tyrosine phosphorylation of STAT protein	IMP IMP: Inferred from mutant phenotype	16837552	MGI
involved in regulation of cell migration	IMP IMP: Inferred from mutant phenotype	15543145	MGI
involved in synapse assembly	IDA IDA: Inferred from direct assay	20393464	MGI
involved in synapse assembly	IMP IMP: Inferred from mutant phenotype	20393464	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	20393464	MGI
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	20393464	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	20393464	MGI
is active in neuromuscular junction	IDA IDA: Inferred from direct assay	22184199	MGI
is active in neuromuscular junction	IMP IMP: Inferred from mutant phenotype	22184199	MGI
is active in plasma membrane	IDA IDA: Inferred from direct assay	8702723	MGI
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	20393464	MGI
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	20393464	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Erbb4 Protein Structure

Recep_L_domain

Furin-like

Recep_L_domain

GF_recep_IV

TM_ErbB4

PTKc_HER4

0
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800
1000
1200
1292 a.a.

Protein Preferred Names

Protein Names

receptor tyrosine-protein kinase erbB-4

avian erythroblastosis oncogene B 4	proto-oncogene-like protein c-ErbB-4
v-erb-a erythroblastic leukemia viral oncogene homolog 4

Erbb4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Erbb4	Q61527	WWOX	Homo sapiens	Q9NZC7	Confocal	16061658
Cross	Erbb4	Q61527	WWOX	Homo sapiens	Q9NZC7	Anti Tag CoIP	16061658

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13272	Dacomitinib		99.74%	Yes

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0793	AZ-5104	Inhibitor	99.69%	Unkown
HY-18609	PD158780	Inhibitor	99.56%	Unkown
HY-13427	Allitinib tosylate	Inhibitor	99.83%	Unkown
HY-103440	EGFR/ErbB-2/ErbB-4 inhibitor-3	Inhibitor	98.19%	Unkown
HY-112420	EGFR/ErbB-2/ErbB-4 inhibitor-2	Inhibitor	99.45%	Unkown
HY-103441	JNJ28871063 hydrochloride	Inhibitor	98.36%	Unkown
HY-RS04472	ERBB4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-15375	Allitinib	Inhibitor	99.36%	Unkown
HY-RS04473	Erbb4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04474	Erbb4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Erbb4	NCBI	NCBI:2066
Rattus norvegicus	Erbb4	NCBI	NCBI:59323

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