ATF6B - activating transcription factor 6 beta Gene

Homo sapiens

Also known as G13; CREBL1; CREB-RP

Gene ID: 1388 | Gene type: protein coding

About ATF6B

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:32,115,264-32,128,246 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 189 orthologues and 9 paralogues. Ubiquitous expression in spleen (RPKM 32.2), skin (RPKM 32.1) and 25 other tissues.

Summary

The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

ATF6B Products(2)

mRNA	Protein	Name
NM_001136153.2	NP_001129625.1	cyclic AMP-dependent transcription factor ATF-6 beta isoform b
NM_004381.5	NP_004372.3	cyclic AMP-dependent transcription factor ATF-6 beta isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	14973138	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	11256944	GOA
contributes to RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11256944	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12445808	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	11256944	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of ATF6-mediated unfolded protein response	IDA IDA: Inferred from direct assay	9837962	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11256944	GOA
involved in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	11256944	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	11256944	GOA
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	23661758	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	11256944	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11256944	GOA
part of protein-DNA complex	IDA IDA: Inferred from direct assay	11256944	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATF6B Protein Structure

bZIP_1

0
200
400
600
700 a.a.

Protein Preferred Names

Protein Names

cyclic AMP-dependent transcription factor ATF-6 beta

Creb-related protein

Related Diseases

Diseases

Alias

Kidney Fibrosarcoma

Fibrosarcoma Of The Kidney

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01135	ATF6B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ATF6B	VGNC	VGNC:81026
Mus musculus	ATF6B	MGD	MGI:105121
Bos taurus	ATF6B	VGNC	VGNC:26245
Rattus norvegicus	ATF6B	RGD	RGD:1303317
Felis catus	ATF6B	VGNC	VGNC:59993
Canis familiaris	ATF6B	VGNC	VGNC:52104

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