SLITRK4 - SLIT and NTRK like family member 4 Gene

Homo sapiens

Gene ID: 139065 | Gene type: protein coding

About SLITRK4

Cytogenetic location: Xq27.3 Genomic coordinates (GRCh38): X:143,622,790-143,636,101 (from NCBI)

This gene has 3 transcripts (splice variants), 188 orthologues and 25 paralogues. Biased expression in adrenal (RPKM 4.6), brain (RPKM 4.3) and 9 other tissues.

Summary

This gene encodes a transmembrane protein belonging to the the SLITRK family. These family members include two N-terminal leucine-rich repeat domains similar to those found in the axonal growth-controlling protein SLIT, as well as C-terminal regions similar to neurotrophin receptors. Studies of an homologous protein in mouse suggest that this family member functions to suppress neurite outgrowth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

SLITRK4 Products(3)

mRNA	Protein	Name
NM_001184749.3	NP_001171678.1	SLIT and NTRK-like protein 4 precursor
NM_001184750.2	NP_001171679.1	SLIT and NTRK-like protein 4 precursor
NM_173078.5	NP_775101.1	SLIT and NTRK-like protein 4 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of synapse organization	IDA IDA: Inferred from direct assay	23345436	GOA
involved in regulation of synapse organization	IMP IMP: Inferred from mutant phenotype	23345436	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	23345436	GOA
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	23345436	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLITRK4 Protein Structure

LRR_8

0
200
400
600
837 a.a.

Protein Preferred Names

Protein Names

SLIT and NTRK-like protein 4

slit and trk like gene 4

SLITRK4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SLITRK4	Q8IW52	CNPY3	Homo sapiens	Q9BT09	Anti Tag CoIP	33961781
Intra	SLITRK4	Q8IW52	CNPY3	Homo sapiens	Q9BT09	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SLITRK4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77207	SLITRK4 Protein, Human (HEK293, His)	Q8IW52 (D19-P616)	≥95%

Related Diseases

Diseases

Alias

Supratentorial Primitive Neuroectodermal Tumor

Supratentorial Pnet	Supratentorial Embryonal Tumor, Not Otherwise Specified
Ewings Sarcoma-Primitive Neuroectodermal Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13376	SLITRK4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SLITRK4	MGD	MGI:2442509
Macaca mulatta	SLITRK4	VGNC	VGNC:77762
Rattus norvegicus	SLITRK4	RGD	RGD:1588563
Bos taurus	SLITRK4	VGNC	VGNC:34965
Canis familiaris	SLITRK4	VGNC	VGNC:46509
Others	SLITRK4	NCBI

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