FOXR2 - forkhead box R2 Gene

Homo sapiens

Also known as FOXN6

Gene ID: 139628 | Gene type: protein coding

About FOXR2

Cytogenetic location: Xp11.21 Genomic coordinates (GRCh38): X:55,623,400-55,626,192 (from NCBI)

This gene has 1 transcript (splice variant), 131 orthologues and 42 paralogues.

Summary

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

FOXR2 Products(1)

mRNA	Protein	Name
NM_198451.4	NP_940853.1	forkhead box protein R2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOXR2 Protein Structure

Forkhead

0
100
200
311 a.a.

Protein Preferred Names

Protein Names

forkhead box protein R2

forkhead box protein N6

FOXR2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FOXR2	Q6PJQ5	PEF1	Homo sapiens	Q9UBV8	Y2H Prey Pooling	25416956
Intra	FOXR2	Q6PJQ5	PEF1	Homo sapiens	Q9UBV8	Validated Y2H	25416956
Intra	FOXR2	Q6PJQ5	PEF1	Homo sapiens	Q9UBV8	Validated Y2H	32296183
Intra	FOXR2	Q6PJQ5	PEF1	Homo sapiens	Q9UBV8	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cns Neuroblastoma With Foxr2 Activation

Central Nervous System Neuroblastoma With Foxr2 Activation	Cns Nb-Foxr2
Cns Neuroblastoma, Foxr2-Activated

Central Nervous System Neuroblastoma

Central Nervous System Germ Cell Tumor

Central Nervous System Germ Cell Tumour	Germ Cell Tumor Of The Cns
Germ Cell Tumour Of The Cns

Pineal Gland Cancer

Tumor Of The Pineal Region	Malignant Pineal Region Tumor
Malignant Tumor Of Pineal Gland	Neoplasm Of Pineal Gland
Neoplasm Of The Pineal Region	Pineal Body Neoplasm
Pineocytic Tumor	Malignant Neoplasm Of Pineal Gland
Pineal Gland Neoplasm	Pineocytoma

Pineoblastoma

Pineal Pnet	Pinealoma
Pineal Gland Neoplasm	Pineocytoma
Tumor Of The Pineal Region

Pineal Parenchymal Tumor Of Intermediate Differentiation

Pineal Parenchymal Tumour Of Intermediate Differentiation	Pineal Parenchymal Tumors Of Intermediate Differentiation
Pptid

Supratentorial Primitive Neuroectodermal Tumor

Supratentorial Pnet	Supratentorial Embryonal Tumor, Not Otherwise Specified
Ewings Sarcoma-Primitive Neuroectodermal Tumor

Solitary Fibrous Tumor/Hemangiopericytoma

Sft/Hpc

Astroblastoma

Cerebral Astroblastoma

Medulloepithelioma

Diktyoma, Malignant	Medulloepithelioma, Central Nervous System
Medulloepithelioma Of The Central Nervous System

Embryonal Tumor With Multilayered Rosettes, C19mc-Altered

Ependymoblastoma

Central Nervous System Primitive Neuroectodermal Neoplasm

Cpnet

Atypical Teratoid Rhabdoid Tumor

Rhabdoid Tumor Predisposition Syndrome	Rtps
Atypical Teratoid/Rhabdoid Tumor	Rhabdoid Predisposition Syndrome
Familial Posterior Fossa Brain Tumor Of Infancy	Familial Rhabdoid Tumor
At/Rt	Atypical Teratoid Rhabdoid Tumour
Atypical Teratoid/Rhabdoid Tumour	Rhabdoid Tumor Of The Cns
Rhabdoid Tumour Of The Cns	Familial Posterior Fossa Brain Tumor Syndrome
Hereditary Swi/Snf Deficiency Syndrome	Atrt

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05079	FOXR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	FOXR2	VGNC	VGNC:40970
Mus musculus	FOXR2	MGD	MGI:3511682
Bos taurus	FOXR2	VGNC	VGNC:29105
Rattus norvegicus	FOXR2	RGD	RGD:1564437

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