CHODL - chondrolectin Gene

Homo sapiens

Also known as MT75; PRED12; C21orf68

Gene ID: 140578 | Gene type: protein coding

About CHODL

Cytogenetic location: 21q21.1 Genomic coordinates (GRCh38): 21:17,917,340-18,267,370 (from NCBI)

This gene has 7 transcripts (splice variants), 200 orthologues and 1 paralogue. Biased expression in testis (RPKM 14.8), spleen (RPKM 3.6) and 5 other tissues.

Summary

This gene encodes a type I membrane protein with a carbohydrate recognition domain characteristic of C-type lectins in its extracellular portion. In Other proteins, this domain is involved in endocytosis of glycoproteins and exogenous sugar-bearing pathogens. This protein localizes predominantly to the perinuclear region. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

CHODL Products(6)

mRNA	Protein	Name
NM_001204174.2	NP_001191103.1	chondrolectin isoform b
NM_001204175.2	NP_001191104.1	chondrolectin isoform c
NM_001204176.2	NP_001191105.1	chondrolectin isoform c
NM_001204177.2	NP_001191106.1	chondrolectin isoform d
NM_001204178.2	NP_001191107.1	chondrolectin isoform d
NM_024944.3	NP_079220.2	chondrolectin isoform a precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables hyaluronic acid binding	IDA IDA: Inferred from direct assay	12079284	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	22042635	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	12079284	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHODL Protein Structure

Lectin_C

0
100
200
273 a.a.

Protein Preferred Names

Protein Names

chondrolectin

transmembrane protein MT75

CHODL Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CHODL	Q9H9P2	NINJ2	Homo sapiens	Q9NZG7	Validated Y2H	32296183
Intra	CHODL	Q9H9P2	DOLK	Homo sapiens	Q9UPQ8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CHODL Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77897	CHODL Protein, Human (HEK293, Fc)	Q9H9P2-1 (R22-N216)	≥95%

Related Diseases

Diseases

Alias

Enterokinase Deficiency

Enteropeptidase Deficiency	Congenital Enterokinase Deficiency
Congenital Enteropathy Due To Enteropeptidase Deficiency	Deficiency Of Enteropeptidase
ENTKD

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02651	CHODL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CHODL	RGD	RGD:1309885
Bos taurus	CHODL	VGNC	VGNC:27308
Mus musculus	CHODL	MGD	MGI:2179069
Canis familiaris	CHODL	VGNC	VGNC:39225
Macaca mulatta	CHODL	VGNC	VGNC:70985
Felis catus	CHODL	VGNC	VGNC:60867
Others	CHODL	NCBI

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