NINJ2 - ninjurin 2 Gene

Homo sapiens

Gene ID: 4815 | Gene type: protein coding

About NINJ2

Cytogenetic location: 12p13.33 Genomic coordinates (GRCh38): 12:564,296-663,445 (from NCBI)

This gene has 6 transcripts (splice variants), 191 orthologues and 1 paralogue. Broad expression in lung (RPKM 12.3), bone marrow (RPKM 6.0) and 21 other tissues.

Summary

The protein encoded by this gene belongs to the ninjurin (for nerve injury induced) family. It is a cell surface adhesion protein that is upregulated in Schwann cells surrounding the distal segment of injured nerve, and promotes neurite outgrowth, thus may have a role in nerve regeneration after nerve injury. [provided by RefSeq, Oct 2011]

NINJ2 Products(4)

mRNA	Protein	Name
NM_001294345.2	NP_001281274.1	ninjurin-2 isoform 2
NM_001294346.2	NP_001281275.1	ninjurin-2 isoform 3
NM_001367996.1	NP_001354925.1	ninjurin-2 isoform 3
NM_016533.6	NP_057617.3	ninjurin-2 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables membrane destabilizing activity	IDA IDA: Inferred from direct assay	33472215	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
NOT involved in cytolysis	IDA IDA: Inferred from direct assay	33472215	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NINJ2 Protein Structure

Ninjurin

0
100
188 a.a.

Protein Preferred Names

Protein Names

ninjurin-2

nerve injury-induced protein 2

NINJ2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NINJ2	Q9NZG7	LDLRAD1	Homo sapiens	Q5T700	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	LDLRAD1	Homo sapiens	Q5T700	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	JAGN1	Homo sapiens	Q8N5M9	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	JAGN1	Homo sapiens	Q8N5M9	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	IFNGR1	Homo sapiens	P15260	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	IFNGR1	Homo sapiens	P15260	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	LYVE1	Homo sapiens	Q9Y5Y7	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	LYVE1	Homo sapiens	Q9Y5Y7	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	LYVE1	Homo sapiens	Q9Y5Y7	Validated Y2H	32296183
Intra	NINJ2	Q9NZG7	VMA21	Homo sapiens	Q3ZAQ7	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	VMA21	Homo sapiens	Q3ZAQ7	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	GJA1	Homo sapiens	P17302	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	GJA1	Homo sapiens	P17302	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	ELOVL5	Homo sapiens	Q9NYP7	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	ELOVL5	Homo sapiens	Q9NYP7	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	STX2	Homo sapiens	P32856-2	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	STX2	Homo sapiens	P32856-2	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	CLEC17A	Homo sapiens	Q6ZS10	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	CLEC17A	Homo sapiens	Q6ZS10	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	KCNJ6	Homo sapiens	P48051	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	KCNJ6	Homo sapiens	P48051	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	FNDC9	Homo sapiens	Q8TBE3	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	FNDC9	Homo sapiens	Q8TBE3	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	MR1	Homo sapiens	Q95460-2	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	MR1	Homo sapiens	Q95460-2	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	TMPRSS2	Homo sapiens	O15393-2	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	TMPRSS2	Homo sapiens	O15393-2	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	RIC3	Homo sapiens	Q7Z5B4-5	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	RIC3	Homo sapiens	Q7Z5B4-5	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	ODF4	Homo sapiens	Q2M2E3	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	ODF4	Homo sapiens	Q2M2E3	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	CEACAM3	Homo sapiens	P40198	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	CEACAM3	Homo sapiens	P40198	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	SLC66A1	Homo sapiens	Q6ZP29-3	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	SLC66A1	Homo sapiens	Q6ZP29-3	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	SLC7A8	Homo sapiens	Q9UHI5	Validated Y2H	32296183
Intra	NINJ2	Q9NZG7	SLC7A8	Homo sapiens	Q9UHI5	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	SLC7A8	Homo sapiens	Q9UHI5	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	LYPD5	Homo sapiens	Q6UWN5	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	LYPD5	Homo sapiens	Q6UWN5	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	EREG	Homo sapiens	O14944	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	EREG	Homo sapiens	O14944	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	KIR3DL3	Homo sapiens	Q8N743	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	KIR3DL3	Homo sapiens	Q8N743	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	CHODL	Homo sapiens	Q9H9P2	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	CHODL	Homo sapiens	Q9H9P2	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	IL3RA	Homo sapiens	P26951	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	IL3RA	Homo sapiens	P26951	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	PIGP	Homo sapiens	P57054	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	PIGP	Homo sapiens	P57054	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	EVI2B	Homo sapiens	P34910-2	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	EVI2B	Homo sapiens	P34910-2	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	BTNL9	Homo sapiens	Q6UXG8-3	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	BTNL9	Homo sapiens	Q6UXG8-3	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	ERVFRD-1	Homo sapiens	P60508	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	ERVFRD-1	Homo sapiens	P60508	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	CPLX4	Homo sapiens	Q7Z7G2	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	CPLX4	Homo sapiens	Q7Z7G2	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	TM4SF20	Homo sapiens	Q53R12	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	TM4SF20	Homo sapiens	Q53R12	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	GPR42	Homo sapiens	O15529	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	GPR42	Homo sapiens	O15529	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	SLAMF8	Homo sapiens	Q9P0V8	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	SLAMF8	Homo sapiens	Q9P0V8	Validated Y2H	32296183
Intra	NINJ2	Q9NZG7	SLAMF8	Homo sapiens	Q9P0V8	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	TMEM52B	Homo sapiens	Q4KMG9	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	TMEM52B	Homo sapiens	Q4KMG9	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	VSIG1	Homo sapiens	Q86XK7	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	VSIG1	Homo sapiens	Q86XK7	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	RNASEK	Homo sapiens	Q6P5S7	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	RNASEK	Homo sapiens	Q6P5S7	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	ELOVL4	Homo sapiens	Q9GZR5	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	ELOVL4	Homo sapiens	Q9GZR5	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	FAM210B	Homo sapiens	Q96KR6	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	FAM210B	Homo sapiens	Q96KR6	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	AMIGO1	Homo sapiens	Q86WK6	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	AMIGO1	Homo sapiens	Q86WK6	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	TSPAN12	Homo sapiens	O95859	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	TSPAN12	Homo sapiens	O95859	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	TMEM86B	Homo sapiens	Q8N661	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	CYBC1	Homo sapiens	Q9BQA9	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	CYBC1	Homo sapiens	Q9BQA9	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	LHFPL5	Homo sapiens	Q8TAF8	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	LHFPL5	Homo sapiens	Q8TAF8	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	FCGRT	Homo sapiens	P55899	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	FCGRT	Homo sapiens	P55899	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	CD69	Homo sapiens	Q07108	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	CD69	Homo sapiens	Q07108	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	M6PR	Homo sapiens	P20645	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	M6PR	Homo sapiens	P20645	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	PVR	Homo sapiens	P15151	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	PVR	Homo sapiens	P15151	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	TMEM101	Homo sapiens	Q96IK0	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	TMEM101	Homo sapiens	Q96IK0	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	SLC10A1	Homo sapiens	Q14973	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	SLC10A1	Homo sapiens	Q14973	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	CLEC7A	Homo sapiens	Q9BXN2	Y2H Array	25416956
Intra	NINJ2	Q9NZG7	FCRL4	Homo sapiens	Q96PJ5	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	FCRL4	Homo sapiens	Q96PJ5	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	SLC7A14	Homo sapiens	Q8TBB6	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	SLC7A14	Homo sapiens	Q8TBB6	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	MMGT1	Homo sapiens	Q8N4V1	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	MMGT1	Homo sapiens	Q8N4V1	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	NINJ2	Q9NZG7	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	TMEM139	Homo sapiens	Q8IV31	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	TMEM139	Homo sapiens	Q8IV31	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	TMEM9	Homo sapiens	Q9P0T7	Validated Y2H	32296183
Intra	NINJ2	Q9NZG7	TMEM9	Homo sapiens	Q9P0T7	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	TMEM9	Homo sapiens	Q9P0T7	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	MGST3	Homo sapiens	O14880	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	MGST3	Homo sapiens	O14880	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	ICAM3	Homo sapiens	P32942	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	ICAM3	Homo sapiens	P32942	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	TMEM51	Homo sapiens	Q9NW97	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	TMEM51	Homo sapiens	Q9NW97	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	BCL2L13	Homo sapiens	Q9BXK5	Validated Y2H	25416956
Intra	NINJ2	Q9NZG7	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	NINJ2	Q9NZG7	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	KIR2DL3	Homo sapiens	P43628	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	KIR2DL3	Homo sapiens	P43628	Y2H Array	32296183
Intra	NINJ2	Q9NZG7	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	NINJ2	Q9NZG7	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Inflammatory Bowel Disease 4

IBD4

Idiopathic Peripheral Autonomic Neuropathy

Acrocallosal Syndrome

ACLS	Schinzel Acrocallosal Syndrome
Joubert Syndrome 12	Schinzel Syndrome 1
Acrocallosal Syndrome, Schinzel Type	Hallux Duplication, Postaxial Polydactyly, And Absence Of Corpus Callosum
Acs	Absence Of Corpus Callosum With Unusual Facial Appearance, Mental Deficiency, Duplication Of The Halluces And Polydactyly
Hallux Duplication Postaxial Polydactyly And Absence Of Corpus Callosum	JBTS12
Acrocallosal Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09299	NINJ2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NINJ2	VGNC	VGNC:32079
Canis familiaris	NINJ2	VGNC	VGNC:43812
Felis catus	NINJ2	VGNC	VGNC:68496
Mus musculus	NINJ2	MGD	MGI:1352751
Rattus norvegicus	NINJ2	RGD	RGD:620552

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