2. Gene
  3. Chek1 - checkpoint kinase 1 Gene

Chek1 - checkpoint kinase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 140583 | Gene type: protein coding

About Chek1

Primary_assembly 8: 36,420,569-36,441,009 reverse strand.mRatBN7.2:CM026981.1

This gene has 3 transcripts (splice variants), 178 orthologues and is associated with 11 phenotypes. Biased expression in Thymus (RPKM 6.4), Spleen (RPKM 33.5) and 9 other tissues.

Summary

Enables protein kinase activity. Involved in several processes, including DNA damage induced protein phosphorylation; cellular response to caffeine; and negative regulation of G2/M transition of mitotic cell cycle. Predicted to be located in several cellular components, including centrosome; chromosome; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Predicted to colocalize with chromosome, telomeric region. Human ortholog(s) of this gene implicated in pancreatic Cancer. Orthologous to human CHEK1 (checkpoint kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Chek1 Products(2)

mRNA Protein Name
NM_080400.2 NP_536325.1 serine/threonine-protein kinase Chk1
NM_080400.2 NP_536325.1 serine/threonine-protein kinase Chk1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
11687578 RGD
enables protein kinase activity IDA
IDA: Inferred from direct assay
11278490 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to caffeine IEP
IEP: Inferred from expression pattern
11278490 RGD
involved in negative regulation of DNA biosynthetic process IMP
IMP: Inferred from mutant phenotype
12429946 RGD
involved in negative regulation of G2/M transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
11278490 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
11278490 RGD
involved in signal transduction in response to DNA damage IMP
IMP: Inferred from mutant phenotype
11278490 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Chek1 Protein Structure

STKc_Chk1

STKc_Chk1: cd14069 (6 - 264)

  • 0
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  • 476 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase Chk1

CHK1 checkpoint homolog

checkpoint kinase 1 homolog

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-148065 FMF-06-098-1 / Unkown
HY-RS02616 CHEK1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS02617 Chek1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS02618 Chek1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chek1 NCBI NCBI:1111
Mus musculus Chek1 NCBI NCBI:12649