F2rl1 - coagulation factor II (thrombin) receptor-like 1 Gene

Mus musculus

Also known as Par2; PAR-2; Gpcr11

Gene ID: 14063 | Gene type: protein coding

About F2rl1

Chromosome 13: 95,648,240-95,661,735 reverse strand.GRCm39:CM001006.3

This gene has 1 transcript (splice variant), 307 orthologues, 16 paralogues and is associated with 27 phenotypes. Broad expression in colon adult (RPKM 22.6), large intestine adult (RPKM 21.9) and 15 other tissues.

Summary

Enables G protein-coupled receptor activity; G-protein alpha-subunit binding activity; and G-protein beta-subunit binding activity. Involved in several processes, including mature conventional dendritic cell differentiation; positive regulation of cytokine production; and positive regulation of intracellular signal transduction. Located in pseudopodium. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skin. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and respiratory allergy. Orthologous to human F2RL1 (F2R like trypsin receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

F2rl1 Products(1)

mRNA	Protein	Name
NM_007974.4	NP_032000.3	proteinase-activated receptor 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled receptor activity	IMP IMP: Inferred from mutant phenotype	20215560	MGI
enables G-protein alpha-subunit binding	IDA IDA: Inferred from direct assay	20215560	MGI
enables G-protein beta-subunit binding	IDA IDA: Inferred from direct assay	20215560	MGI
enables proteinase-activated receptor activity	IMP IMP: Inferred from mutant phenotype	17992256	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell activation involved in immune response	IDA IDA: Inferred from direct assay	19845798	MGI
involved in defense response to virus	IDA IDA: Inferred from direct assay	19494303	MGI
involved in leukocyte proliferation	IDA IDA: Inferred from direct assay	19494303	MGI
involved in mature conventional dendritic cell differentiation	IDA IDA: Inferred from direct assay	19845798	MGI
involved in negative regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	17992256	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	20215560	MGI
involved in positive regulation of Rho protein signal transduction	IDA IDA: Inferred from direct assay	20215560	MGI
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	20215560	MGI
involved in positive regulation of chemokine production	IDA IDA: Inferred from direct assay	19494303	MGI
involved in positive regulation of chemotaxis	IDA IDA: Inferred from direct assay	12821670	MGI
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	20215560	MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	20215560	MGI
involved in positive regulation of pseudopodium assembly	IDA IDA: Inferred from direct assay	12821670	MGI
involved in positive regulation of renin secretion into blood stream	IDA IDA: Inferred from direct assay	21859963	MGI
involved in positive regulation of type II interferon production	IDA IDA: Inferred from direct assay	19494303	MGI
involved in potassium channel activating, G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17992256	MGI
involved in vasodilation	IDA IDA: Inferred from direct assay	21859963	MGI
acts upstream of or within positive effect vasodilation	IMP IMP: Inferred from mutant phenotype	9918574	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in pseudopodium	IDA IDA: Inferred from direct assay	12821670	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

F2rl1 Protein Structure

7tmA_PAR2

0
100
200
300
399 a.a.

Protein Preferred Names

Protein Names

proteinase-activated receptor 2

G-protein coupled receptor 11	Protease-activated receptor-2
coagulation factor II receptor-like 1	thrombin receptor-like 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04634	F2RL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04635	F2rl1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04636	F2rl1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	F2rl1	NCBI	NCBI:2150

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