1. Gene
  2. ROMO1 - reactive oxygen species modulator 1 Gene

ROMO1 - reactive oxygen species modulator 1 Gene

Homo sapiens

Also known as MTGM; MTGMP; C20orf52; bA353C18.2

Gene ID: 140823 | Gene type: protein coding

About ROMO1

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:35,699,405-35,700,980 (from NCBI)

This gene has 5 transcripts (splice variants) and 208 orthologues. Ubiquitous expression in colon (RPKM 37.6), kidney (RPKM 33.9) and 25 other tissues.

Summary

The protein encoded by this gene is a mitochondrial membrane protein that is responsible for increasing the level of Reactive Oxygen Species (ROS) in cells. The protein also has antimicrobial activity against a variety of bacteria by inducing Bacterial membrane breakage. [provided by RefSeq, Nov 2014]

ROMO1 Products(1)

mRNA Protein Name
NM_080748.3 NP_542786.1 reactive oxygen species modulator 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables monoatomic cation transmembrane transporter activity IDA
IDA: Inferred from direct assay
29545371 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IMP
IMP: Inferred from mutant phenotype
22083756 GOA
involved in cellular response to reactive oxygen species IMP
IMP: Inferred from mutant phenotype
18836179 GOA
involved in cytolysis by host of symbiont cells IDA
IDA: Inferred from direct assay
22083756 GOA
involved in defense response to Gram-negative bacterium IDA
IDA: Inferred from direct assay
22083756 GOA
involved in defense response to Gram-negative bacterium IMP
IMP: Inferred from mutant phenotype
22083756 GOA
involved in defense response to Gram-positive bacterium IDA
IDA: Inferred from direct assay
22083756 GOA
involved in defense response to bacterium IDA
IDA: Inferred from direct assay
22083756 GOA
involved in killing of cells of another organism IDA
IDA: Inferred from direct assay
22083756 GOA
involved in killing of cells of another organism IMP
IMP: Inferred from mutant phenotype
22083756 GOA
involved in monoatomic cation transmembrane transport IDA
IDA: Inferred from direct assay
29545371 GOA
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
18313394 GOA
involved in positive regulation of reactive oxygen species metabolic process IDA
IDA: Inferred from direct assay
16842742 GOA
involved in protein insertion into mitochondrial inner membrane IMP
IMP: Inferred from mutant phenotype
30598479 GOA
involved in replicative senescence IMP
IMP: Inferred from mutant phenotype
18836179 GOA
Cellular Component GO Annotation Evidence Reference Source
part of TIM23 mitochondrial import inner membrane translocase complex IDA
IDA: Inferred from direct assay
30598479 GOA
is active in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
29545371 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
16842742 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ROMO1 Protein Structure

Romo1

Romo1: Reactive mitochondrial oxygen species modulator 1 (13 - 79)

  • 0
  • 79 a.a.
Protein Preferred Names Protein Names

reactive oxygen species modulator 1

PCM19

ROMO1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ROMO1 P60602 RHBDD2 Homo sapiens Q6NTF9-3 32296183
Intra
ROMO1 P60602 RHBDD2 Homo sapiens Q6NTF9-3 32296183
Intra
ROMO1 P60602 RHBDD2 Homo sapiens Q6NTF9-3 32296183
Intra
ROMO1 P60602 CIDEB Homo sapiens Q9UHD4 32296183
Intra
ROMO1 P60602 CIDEB Homo sapiens Q9UHD4 32296183
Intra
ROMO1 P60602 CIDEB Homo sapiens Q9UHD4 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Premature Ovarian Failure 19

POF19

Primary Ovarian Insufficiency 19

Poi19

Ovarian Failure, Premature, Type 19

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta ROMO1 VGNC VGNC:108028
Mus musculus ROMO1 MGD MGI:1914317
Felis catus ROMO1 VGNC VGNC:81211
Rattus norvegicus ROMO1 RGD RGD:1587111
Canis familiaris ROMO1 VGNC VGNC:45691
Bos taurus ROMO1 VGNC VGNC:34085