ROMO1 - reactive oxygen species modulator 1 Gene

Homo sapiens

Also known as MTGM; MTGMP; C20orf52; bA353C18.2

Gene ID: 140823 | Gene type: protein coding

About ROMO1

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:35,699,405-35,700,980 (from NCBI)

This gene has 5 transcripts (splice variants) and 208 orthologues. Ubiquitous expression in colon (RPKM 37.6), kidney (RPKM 33.9) and 25 other tissues.

Summary

The protein encoded by this gene is a mitochondrial membrane protein that is responsible for increasing the level of Reactive Oxygen Species (ROS) in cells. The protein also has antimicrobial activity against a variety of bacteria by inducing Bacterial membrane breakage. [provided by RefSeq, Nov 2014]

ROMO1 Products(1)

mRNA	Protein	Name
NM_080748.3	NP_542786.1	reactive oxygen species modulator 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables monoatomic cation transmembrane transporter activity	IDA IDA: Inferred from direct assay	29545371	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IMP IMP: Inferred from mutant phenotype	22083756	GOA
involved in cellular response to reactive oxygen species	IMP IMP: Inferred from mutant phenotype	18836179	GOA
involved in cytolysis by host of symbiont cells	IDA IDA: Inferred from direct assay	22083756	GOA
involved in defense response to Gram-negative bacterium	IDA IDA: Inferred from direct assay	22083756	GOA
involved in defense response to Gram-negative bacterium	IMP IMP: Inferred from mutant phenotype	22083756	GOA
involved in defense response to Gram-positive bacterium	IDA IDA: Inferred from direct assay	22083756	GOA
involved in defense response to bacterium	IDA IDA: Inferred from direct assay	22083756	GOA
involved in killing of cells of another organism	IDA IDA: Inferred from direct assay	22083756	GOA
involved in killing of cells of another organism	IMP IMP: Inferred from mutant phenotype	22083756	GOA
involved in monoatomic cation transmembrane transport	IDA IDA: Inferred from direct assay	29545371	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	18313394	GOA
involved in positive regulation of reactive oxygen species metabolic process	IDA IDA: Inferred from direct assay	16842742	GOA
involved in protein insertion into mitochondrial inner membrane	IMP IMP: Inferred from mutant phenotype	30598479	GOA
involved in replicative senescence	IMP IMP: Inferred from mutant phenotype	18836179	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of TIM23 mitochondrial import inner membrane translocase complex	IDA IDA: Inferred from direct assay	30598479	GOA
is active in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	29545371	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	16842742	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ROMO1 Protein Structure

Romo1

0
79 a.a.

Protein Preferred Names

Protein Names

reactive oxygen species modulator 1

PCM19

ROMO1 Protein-protein interaction Information

Type Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ROMO1	P60602	RHBDD2	Homo sapiens	Q6NTF9-3	Validated Y2H	32296183
Intra	ROMO1	P60602	RHBDD2	Homo sapiens	Q6NTF9-3	Y2H Array	32296183
Intra	ROMO1	P60602	RHBDD2	Homo sapiens	Q6NTF9-3	Y2H Prey Pooling	32296183
Intra	ROMO1	P60602	CIDEB	Homo sapiens	Q9UHD4	Y2H Prey Pooling	32296183
Intra	ROMO1	P60602	CIDEB	Homo sapiens	Q9UHD4	Y2H Array	32296183
Intra	ROMO1	P60602	CIDEB	Homo sapiens	Q9UHD4	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Premature Ovarian Failure 19

POF19	Primary Ovarian Insufficiency 19
Poi19	Ovarian Failure, Premature, Type 19

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect Pre-designed Sets	Purity	Rare Diseases Unkown
HY-RS12122	ROMO1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ROMO1	VGNC	VGNC:108028
Mus musculus	ROMO1	MGD	MGI:1914317
Felis catus	ROMO1	VGNC	VGNC:81211
Rattus norvegicus	ROMO1	RGD	RGD:1587111
Canis familiaris	ROMO1	VGNC	VGNC:45691
Bos taurus	ROMO1	VGNC	VGNC:34085

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