CIDEB - cell death inducing DFFA like effector b Gene

Homo sapiens

Gene ID: 27141 | Gene type: protein coding

About CIDEB

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:24,305,187-24,311,435 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 192 orthologues and 3 paralogues. Ubiquitous expression in liver (RPKM 36.3), duodenum (RPKM 31.8) and 24 other tissues.

Summary

Enables identical protein binding activity. Involved in activation of cysteine-type endopeptidase activity; positive regulation of cell death; and positive regulation of release of cytochrome c from mitochondria. Acts upstream of or within apoptotic process. Located in cytosol and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

CIDEB Products(9)

mRNA	Protein	Name
NM_001318807.3	NP_001305736.1	cell death activator CIDE-B isoform 1
NM_001393334.1	NP_001380263.1	cell death activator CIDE-B isoform 1
NM_001393335.1	NP_001380264.1	cell death activator CIDE-B isoform 1
NM_001393336.1	NP_001380265.1	cell death activator CIDE-B isoform 1
NM_001393337.1	NP_001380266.1	cell death activator CIDE-B isoform 1
NM_001393338.1	NP_001380267.1	cell death activator CIDE-B isoform 1
NM_001393339.1	NP_001380268.1	cell death activator CIDE-B isoform 1
NM_001393340.1	NP_001380269.1	cell death activator CIDE-B isoform 2
NM_014430.4	NP_055245.2	cell death activator CIDE-B isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	12595532	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12595532	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within apoptotic process	IDA IDA: Inferred from direct assay	12429024	GOA
involved in lipid droplet fusion	IMP IMP: Inferred from mutant phenotype	35939579	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	12595532	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	12429024	GOA
is active in lipid droplet	IDA IDA: Inferred from direct assay	35939579	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	12595532	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CIDEB Protein Structure

CIDE-N

0
100
200
219 a.a.

Protein Preferred Names

Protein Names

cell death activator CIDE-B

CIDEB Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CIDEB	Q9UHD4	NDRG4	Homo sapiens	Q9ULP0-2	Validated Y2H	32296183
Intra	CIDEB	Q9UHD4	APOC1	Homo sapiens	P02654	Y2H Array	32296183
Intra	CIDEB	Q9UHD4	APOC1	Homo sapiens	P02654	Y2H Prey Pooling	32296183
Intra	CIDEB	Q9UHD4	RHBDD2	Homo sapiens	Q6NTF9-3	Y2H Prey Pooling	32296183
Intra	CIDEB	Q9UHD4	RHBDD2	Homo sapiens	Q6NTF9-3	Y2H Array	32296183
Intra	CIDEB	Q9UHD4	LAMP2	Homo sapiens	P13473-2	Y2H Array	32814053
Intra	CIDEB	Q9UHD4	LAMP2	Homo sapiens	P13473-2	Y2H Pooling	32814053
Intra	CIDEB	Q9UHD4	LAMP2	Homo sapiens	P13473-2	Validated Y2H	32814053
Intra	CIDEB	Q9UHD4	SH3GLB1	Homo sapiens	Q9Y371	Y2H Array	32814053
Intra	CIDEB	Q9UHD4	SH3GLB1	Homo sapiens	Q9Y371	Validated Y2H	32814053
Intra	CIDEB	Q9UHD4	SH3GLB1	Homo sapiens	Q9Y371	Y2H Pooling	32814053
Intra	CIDEB	Q9UHD4	NAALAD2	Homo sapiens	Q9Y3Q0	Validated Y2H	32296183
Intra	CIDEB	Q9UHD4	TAOK2	Homo sapiens	Q9UL54	Validated Y2H	32296183
Intra	CIDEB	Q9UHD4	SAR1B	Homo sapiens	Q9Y6B6	Validated Y2H	32296183
Intra	CIDEB	Q9UHD4	MVB12A	Homo sapiens	Q96EY5	Anti Tag CoIP	33961781
Intra	CIDEB	Q9UHD4	MVB12A	Homo sapiens	Q96EY5	Anti Tag CoIP	28514442
Intra	CIDEB	Q9UHD4	CIDEB	Homo sapiens	Q9UHD4	Y2H Array	32296183
Intra	CIDEB	Q9UHD4	CIDEB	Homo sapiens	Q9UHD4	Y2H	12595532
Intra	CIDEB	Q9UHD4	CIDEB	Homo sapiens	Q9UHD4	Pull Down	12595532
Intra	CIDEB	Q9UHD4	CIDEB	Homo sapiens	Q9UHD4	Y2H Prey Pooling	32296183
Intra	CIDEB	Q9UHD4	CIDEB	Homo sapiens	Q9UHD4	Validated Y2H	32296183
Intra	CIDEB	Q9UHD4	NFU1	Homo sapiens	Q9UMS0	Validated Y2H	32296183
Intra	CIDEB	Q9UHD4	NME4	Homo sapiens	O00746	Y2H Array	32296183
Cross	CIDEB	Q9UHD4	P27958-PRO_0000037572	Hepatitis C virus	P27958-PRO_0000037572	Y2H	12595532
Cross	CIDEB	Q9UHD4	P27958-PRO_0000037572	Hepatitis C virus	P27958-PRO_0000037572	Pull Down	12595532
Cross	CIDEB	Q9UHD4	P27958-PRO_0000037572	Hepatitis C virus	P27958-PRO_0000037572	Confocal	12595532

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02712	CIDEB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CIDEB	RGD	RGD:1310000
Felis catus	CIDEB	VGNC	VGNC:60901
Bos taurus	CIDEB	VGNC	VGNC:27364
Macaca mulatta	CIDEB	VGNC	VGNC:84324
Mus musculus	CIDEB	MGD	MGI:1270844

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