Fasn - fatty acid synthase Gene

Mus musculus

Also known as FAS; A630082H08Rik

Gene ID: 14104 | Gene type: protein coding

About Fasn

Chromosome 11: 120,696,672-120,715,373 reverse strand.GRCm39:CM001004.3

This gene has 6 transcripts (splice variants), 195 orthologues, 1 paralogue and is associated with 4 phenotypes. Biased expression in mammary gland adult (RPKM 165.), subcutaneous fat pad adult (RPKM 1125.4) and 6 other tissues.

Summary

Enables fatty acid synthase activity. Involved in ether lipid biosynthetic process; mammary gland development; and myeloid leukocyte differentiation. Acts upstream of or within cellular response to interleukin-4; epithelial cell development; and fatty acid biosynthetic process. Located in glycogen granule. Is expressed in several structures, including adipose tissue; alimentary system; nervous system; sensory organ; and skeleton. Orthologous to human FASN (fatty acid synthase). [provided by Alliance of Genome Resources, Apr 2022]

Fasn Products(1)

mRNA	Protein	Name
NM_007988.3	NP_032014.3	fatty acid synthase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables fatty acid synthase activity	IDA IDA: Inferred from direct assay	16054098	MGI
enables fatty acid synthase activity	IMP IMP: Inferred from mutant phenotype	16054078	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular response to interleukin-4	IDA IDA: Inferred from direct assay	9798653	MGI
acts upstream of or within establishment of endothelial intestinal barrier	IMP IMP: Inferred from mutant phenotype	25565205	MGI
involved in ether lipid biosynthetic process	IMP IMP: Inferred from mutant phenotype	25565205	MGI
acts upstream of or within fatty acid biosynthetic process	IDA IDA: Inferred from direct assay	22331133	MGI
acts upstream of or within glandular epithelial cell development	IMP IMP: Inferred from mutant phenotype	25565205	MGI
acts upstream of inflammatory response	IMP IMP: Inferred from mutant phenotype	25565205	MGI
involved in lipid biosynthetic process	IDA IDA: Inferred from direct assay	16054098	MGI
involved in lipid biosynthetic process	IMP IMP: Inferred from mutant phenotype	16054078	MGI
involved in mammary gland development	IMP IMP: Inferred from mutant phenotype	24668799	MGI
involved in monocyte differentiation	IMP IMP: Inferred from mutant phenotype	25565205	MGI
involved in neutrophil differentiation	IMP IMP: Inferred from mutant phenotype	25565205	MGI
acts upstream of or within tissue development	IMP IMP: Inferred from mutant phenotype	25565205	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in glycogen granule	IDA IDA: Inferred from direct assay	15169678	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Fasn Protein Structure

PksD

PKS

Methyltransf_12

KR_1_FAS_SDR_x

PKS_ER

KR_1_FAS_SDR_x

PKS_PP

Thioesterase

0
400
800
1200
1600
2000
2504 a.a.

Protein Preferred Names

Protein Names

fatty acid synthase

type I Fatty Acid Synthase

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0218	Orlistat		99.97%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112829	Denifanstat	Inhibitor	99.58%	Phase 3

Pre-clinical Phase

Bioactive Molecules (31)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12364	C75	Inhibitor	99.91%	Unkown
HY-120394	TVB-3166		99.69%	Unkown
HY-A0210	Cerulenin		99.52%	Unkown
HY-120062	TVB-3664	Inhibitor	99.57%	Unkown
HY-12325	GSK2194069	Inhibitor	99.84%	Unkown
HY-16100	BI 99179	Inhibitor	99.38%	Unkown
HY-124628	IPI-9119	Inhibitor	99.24%	Unkown
HY-12364A	trans-C75	Inhibitor	99.73%	Unkown
HY-12648A	FASN-IN-4 tosylate	Inhibitor	98.55%	Unkown
HY-N2486	Desoxyrhaponticin		99.80%	Unkown
HY-121250	Fasnall		99.54%	Unkown
HY-111551	FT113	Inhibitor	99.39%	Unkown
HY-B0218R	Orlistat (Standard)		99.85%	Unkown
HY-110354	UCM05	Inhibitor	99.58%	Unkown
HY-111777	FASN-IN-1	Inhibitor	99.90%	Unkown
HY-145809	FASN-IN-5	Inhibitor	99.81%	Unkown
HY-RS04754	Fasn Mouse Pre-designed siRNA Set A		/	Unkown
HY-12648	FASN-IN-4	Inhibitor	99.21%	Unkown
HY-U00436	FASN-IN-3	Inhibitor	98.06%	Unkown
HY-117769	GSK837149A	Inhibitor	≥99.0%	Unkown
HY-112522	HS79	Inhibitor	/	Unkown
HY-112522A	HS80	Inhibitor	/	Unkown
HY-12364B	(−)-C75	Inhibitor	/	Unkown
HY-149540	CTL-06	Inhibitor	/	Unkown
HY-149541	CTL-12	Inhibitor	/	Unkown
HY-155282	FASN-IN-6	Inhibitor	/	Unkown
HY-158649	Fasnall benzenesulfonate		/	Unkown
HY-B0218S	Orlistat-d3		/	Unkown
HY-N8144	Niga-ichigoside F1		≥99.0%	Unkown
HY-RS04753	FASN Human Pre-designed siRNA Set A		/	Unkown
HY-RS04755	Fasn Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fasn	NCBI	NCBI:2194

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