Fcgr1 - Fc receptor, IgG, high affinity I Gene

Mus musculus

Also known as CD64; IGGHAFC; FcgammaRI

Gene ID: 14129 | Gene type: protein coding

About Fcgr1

Summary

Enables IgG binding activity and IgG receptor activity. Acts upstream of or within several processes, including antibody-dependent cellular cytotoxicity; endocytosis; and positive regulation of hypersensitivity. Located in external side of plasma membrane. Is expressed in liver. Orthologous to several human genes including FCGR1A (Fc gamma receptor Ia). [provided by Alliance of Genome Resources, Apr 2022]

Fcgr1 Products(1)

mRNA	Protein	Name
NM_010186.5	NP_034316.1	high affinity immunoglobulin gamma Fc receptor I precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables IgG binding	IDA IDA: Inferred from direct assay	9551950	MGI
enables IgG binding	IMP IMP: Inferred from mutant phenotype	11911823	MGI
enables IgG receptor activity	IMP IMP: Inferred from mutant phenotype	9551950	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within antibody-dependent cellular cytotoxicity	IMP IMP: Inferred from mutant phenotype	11911823	MGI
acts upstream of or within antigen processing and presentation of exogenous antigen	IMP IMP: Inferred from mutant phenotype	11911823	MGI
acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class I	IMP IMP: Inferred from mutant phenotype	11911824	MGI
acts upstream of or within cell surface receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9551950	MGI
acts upstream of or within defense response to bacterium	IMP IMP: Inferred from mutant phenotype	11911824	MGI
acts upstream of or within phagocytosis, engulfment	IMP IMP: Inferred from mutant phenotype	9551950	MGI
acts upstream of or within phagocytosis, recognition	IMP IMP: Inferred from mutant phenotype	9551950	MGI
acts upstream of or within positive regulation of phagocytosis	IMP IMP: Inferred from mutant phenotype	9551950	MGI
acts upstream of or within positive regulation of type III hypersensitivity	IMP IMP: Inferred from mutant phenotype	11911823	MGI
acts upstream of or within positive regulation of type IIa hypersensitivity	IMP IMP: Inferred from mutant phenotype	11911824	MGI
acts upstream of or within receptor-mediated endocytosis	IMP IMP: Inferred from mutant phenotype	11911823	MGI
acts upstream of or within regulation of immune response	IMP IMP: Inferred from mutant phenotype	11911823	MGI
acts upstream of or within response to bacterium	IMP IMP: Inferred from mutant phenotype	16836651	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	11911823	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

high affinity immunoglobulin gamma Fc receptor I

IgG high affinity Fc receptor	fc-gamma RI
fcRI	igG Fc receptor I

Recombinant Fcgr1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72714	CD64 Protein, Mouse (HEK293, His)	P26151 (E25-P297)	≥95%
HY-P72927	CD64 Protein, Mouse (HEK293, His-Avi)	P26151 (E25-P297)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04827	FCGR1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source
Canis familiaris	Fcgr1	NCBI
Leporidae	Fcgr1	NCBI
Rattus norvegicus	Fcgr1	NCBI

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