Fgf10 - fibroblast growth factor 10 Gene

Mus musculus

Also known as AEY17; Fgf5a; Fgf-10; Gsfaey17

Gene ID: 14165 | Gene type: protein coding

About Fgf10

Summary

Enables chemoattractant activity. Involved in positive regulation of transcription, DNA-templated and radial glial cell differentiation. Acts upstream of or within several processes, including animal organ development; positive regulation of cell population proliferation; and regulation of signal transduction. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study LADD syndrome and intestinal atresia. Human ortholog(s) of this gene implicated in LADD syndrome and aplasia of lacrimal and salivary glands. Orthologous to human FGF10 (Fibroblast Growth Factor 10). [provided by Alliance of Genome Resources, Apr 2022]

Fgf10 Products(1)

mRNA	Protein	Name
NM_008002.5	NP_032028.1	fibroblast growth factor 10 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chemoattractant activity	IDA IDA: Inferred from direct assay	15531758	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15806171	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of ERK1 and ERK2 cascade	IGI IGI: Inferred from genetic interaction	17202188	MGI
acts upstream of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	15130516	MGI
acts upstream of or within Harderian gland development	IMP IMP: Inferred from mutant phenotype	10964474	MGI
acts upstream of Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	17560563	MGI
acts upstream of or within animal organ formation	IMP IMP: Inferred from mutant phenotype	11062007	MGI
acts upstream of or within animal organ morphogenesis	IDA IDA: Inferred from direct assay	14651921	MGI
acts upstream of or within animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	10964474	MGI
acts upstream of or within blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	17560563	MGI
acts upstream of or within blood vessel remodeling	IGI IGI: Inferred from genetic interaction	17000704	MGI
acts upstream of or within branch elongation involved in salivary gland morphogenesis	IMP IMP: Inferred from mutant phenotype	15972105	MGI
acts upstream of or within branching involved in salivary gland morphogenesis	IDA IDA: Inferred from direct assay	18559345	MGI
acts upstream of or within branching involved in salivary gland morphogenesis	IGI IGI: Inferred from genetic interaction	15972105	MGI
acts upstream of or within bronchiole morphogenesis	IMP IMP: Inferred from mutant phenotype	15800000	MGI
acts upstream of or within bud elongation involved in lung branching	IGI IGI: Inferred from genetic interaction	21764747	MGI
acts upstream of cell population proliferation	IDA IDA: Inferred from direct assay	9428423	MGI
acts upstream of or within cell-cell signaling	IDA IDA: Inferred from direct assay	9428423	MGI
acts upstream of or within cell-cell signaling	IMP IMP: Inferred from mutant phenotype	15199404	MGI
acts upstream of or within chemotaxis	IDA IDA: Inferred from direct assay	16169547	MGI
acts upstream of or within determination of left/right symmetry	IMP IMP: Inferred from mutant phenotype	15329346	MGI
acts upstream of or within digestive tract development	IMP IMP: Inferred from mutant phenotype	15234214	MGI
acts upstream of or within embryonic camera-type eye development	IMP IMP: Inferred from mutant phenotype	15958512	MGI
acts upstream of or within embryonic digestive tract development	IMP IMP: Inferred from mutant phenotype	16308329	MGI
acts upstream of or within embryonic digestive tract morphogenesis	IMP IMP: Inferred from mutant phenotype	15017552	MGI
acts upstream of or within embryonic genitalia morphogenesis	IMP IMP: Inferred from mutant phenotype	12004962	MGI
acts upstream of or within embryonic pattern specification	IMP IMP: Inferred from mutant phenotype	16618415	MGI
acts upstream of endothelial cell proliferation	IDA IDA: Inferred from direct assay	14697353	MGI
acts upstream of or within epidermis development	IMP IMP: Inferred from mutant phenotype	10984614	MGI
acts upstream of or within epidermis morphogenesis	IMP IMP: Inferred from mutant phenotype	14530295	MGI
acts upstream of epithelial cell differentiation	IDA IDA: Inferred from direct assay	14604677	MGI
acts upstream of or within epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	16618415	MGI
acts upstream of epithelial cell proliferation	IDA IDA: Inferred from direct assay	9428423	MGI
acts upstream of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	15972105	MGI
acts upstream of or within epithelial cell proliferation involved in salivary gland morphogenesis	IGI IGI: Inferred from genetic interaction	15972105	MGI
acts upstream of or within epithelial cell proliferation involved in salivary gland morphogenesis	IMP IMP: Inferred from mutant phenotype	15972105	MGI
acts upstream of or within epithelial tube branching involved in lung morphogenesis	IDA IDA: Inferred from direct assay	9428423	MGI
acts upstream of or within epithelial tube branching involved in lung morphogenesis	IMP IMP: Inferred from mutant phenotype	9784490	MGI
acts upstream of or within establishment of mitotic spindle orientation	IGI IGI: Inferred from genetic interaction	21764747	MGI
acts upstream of extrinsic apoptotic signaling pathway in absence of ligand	IMP IMP: Inferred from mutant phenotype	16956603	MGI
acts upstream of or within female genitalia morphogenesis	IMP IMP: Inferred from mutant phenotype	12004962	MGI
acts upstream of or within fibroblast growth factor receptor apoptotic signaling pathway	IDA IDA: Inferred from direct assay	16720875	MGI
acts upstream of or within fibroblast growth factor receptor apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	16720875	MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway involved in mammary gland specification	IDA IDA: Inferred from direct assay	16720875	MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway involved in mammary gland specification	IMP IMP: Inferred from mutant phenotype	16720875	MGI
acts upstream of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	15130516	MGI
acts upstream of or within hair follicle morphogenesis	IMP IMP: Inferred from mutant phenotype	11062007	MGI
acts upstream of or within induction of positive chemotaxis	IDA IDA: Inferred from direct assay	16308329	MGI
acts upstream of or within inner ear morphogenesis	IGI IGI: Inferred from genetic interaction	16691564	MGI
acts upstream of or within inner ear morphogenesis	IMP IMP: Inferred from mutant phenotype	11062007	MGI
acts upstream of keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	10984614	MGI
acts upstream of or within lacrimal gland development	IMP IMP: Inferred from mutant phenotype	10821755	MGI
acts upstream of or within limb bud formation	IMP IMP: Inferred from mutant phenotype	9784490	MGI
acts upstream of or within limb development	IMP IMP: Inferred from mutant phenotype	10804187	MGI
acts upstream of or within limb morphogenesis	IMP IMP: Inferred from mutant phenotype	9916808	MGI
acts upstream of or within lung alveolus development	IGI IGI: Inferred from genetic interaction	16989802	MGI
acts upstream of or within lung alveolus development	IMP IMP: Inferred from mutant phenotype	17560563	MGI
acts upstream of or within lung development	IDA IDA: Inferred from direct assay	9428423	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	9916808	MGI
acts upstream of or within lung morphogenesis	IMP IMP: Inferred from mutant phenotype	15800000	MGI
acts upstream of or within lung proximal/distal axis specification	IDA IDA: Inferred from direct assay	15531758	MGI
acts upstream of or within male genitalia morphogenesis	IMP IMP: Inferred from mutant phenotype	12004962	MGI
acts upstream of or within mammary gland bud formation	IMP IMP: Inferred from mutant phenotype	11782400	MGI
acts upstream of or within mammary gland specification	IGI IGI: Inferred from genetic interaction	16720875	MGI
acts upstream of or within mesenchymal cell differentiation involved in lung development	IGI IGI: Inferred from genetic interaction	16989802	MGI
acts upstream of or within mesenchymal-epithelial cell signaling involved in lung development	IDA IDA: Inferred from direct assay	15531758	MGI
acts upstream of or within metanephros morphogenesis	IMP IMP: Inferred from mutant phenotype	11062007	MGI
acts upstream of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	16956603	MGI
acts upstream of or within muscle cell fate commitment	IMP IMP: Inferred from mutant phenotype	15800000	MGI
acts upstream of or within negative regulation of epithelial cell differentiation	IDA IDA: Inferred from direct assay	14604677	MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP IMP: Inferred from mutant phenotype	16956603	MGI
acts upstream of or within negative regulation of stem cell proliferation	IDA IDA: Inferred from direct assay	16141225	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IMP IMP: Inferred from mutant phenotype	11062007	MGI
acts upstream of or within organ growth	IMP IMP: Inferred from mutant phenotype	16618415	MGI
acts upstream of or within organ induction	IGI IGI: Inferred from genetic interaction	12810586	MGI
acts upstream of or within otic vesicle formation	IGI IGI: Inferred from genetic interaction	14623822	MGI
acts upstream of or within pancreas development	IMP IMP: Inferred from mutant phenotype	15329346	MGI
acts upstream of or within pituitary gland development	IMP IMP: Inferred from mutant phenotype	11062007	MGI
acts upstream of or within positive chemotaxis	IDA IDA: Inferred from direct assay	15531758	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	17394208	MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade	IGI IGI: Inferred from genetic interaction	17202188	MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	15130516	MGI
acts upstream of or within positive regulation of Notch signaling pathway	IGI IGI: Inferred from genetic interaction	16324690	MGI
acts upstream of or within positive regulation of Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	17560563	MGI
acts upstream of or within positive regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	16720875	MGI
acts upstream of or within positive regulation of endothelial cell proliferation	IDA IDA: Inferred from direct assay	14697353	MGI
acts upstream of or within positive regulation of epithelial cell migration	IDA IDA: Inferred from direct assay	15531758	MGI
acts upstream of or within positive regulation of epithelial cell migration	IMP IMP: Inferred from mutant phenotype	15958512	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IDA IDA: Inferred from direct assay	9428423	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	15958512	MGI
acts upstream of or within positive regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	15130516	MGI
acts upstream of or within positive regulation of keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	10984614	MGI
acts upstream of or within positive regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	16956603	MGI
acts upstream of or within positive regulation of stem cell proliferation	IDA IDA: Inferred from direct assay	15199404	MGI
acts upstream of or within positive regulation of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	10984614	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11287183	MGI
acts upstream of or within positive regulation of vascular endothelial growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17560563	MGI
acts upstream of or within positive regulation of white fat cell proliferation	IMP IMP: Inferred from mutant phenotype	15130516	MGI
acts upstream of or within prostatic bud formation	IGI IGI: Inferred from genetic interaction	12941620	MGI
involved in radial glial cell differentiation	IMP IMP: Inferred from mutant phenotype	19607792	MGI
acts upstream of or within regulation of activin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15958512	MGI
acts upstream of or within regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	IDA IDA: Inferred from direct assay	18559345	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	15958512	MGI
acts upstream of or within regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	15958512	MGI
acts upstream of or within respiratory system development	IDA IDA: Inferred from direct assay	11287183	MGI
acts upstream of or within salivary gland morphogenesis	IMP IMP: Inferred from mutant phenotype	15654336	MGI
acts upstream of or within semicircular canal fusion	IMP IMP: Inferred from mutant phenotype	15765517	MGI
acts upstream of or within semicircular canal morphogenesis	IGI IGI: Inferred from genetic interaction	17601531	MGI
acts upstream of or within smooth muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	17560563	MGI
acts upstream of or within somatic stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	11880361	MGI
acts upstream of or within spleen development	IMP IMP: Inferred from mutant phenotype	15329346	MGI
acts upstream of stem cell proliferation	IDA IDA: Inferred from direct assay	15199404	MGI
acts upstream of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	10984614	MGI
acts upstream of or within submandibular salivary gland formation	IMP IMP: Inferred from mutant phenotype	11062007	MGI
acts upstream of or within thyroid gland development	IMP IMP: Inferred from mutant phenotype	11062007	MGI
acts upstream of or within type II pneumocyte differentiation	IDA IDA: Inferred from direct assay	15531758	MGI
acts upstream of vascular endothelial growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17560563	MGI
acts upstream of or within white fat cell differentiation	IMP IMP: Inferred from mutant phenotype	11959839	MGI
acts upstream of white fat cell proliferation	IMP IMP: Inferred from mutant phenotype	15130516	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	9393979	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

fibroblast growth factor 10

fibroblast growth factor 5a

keratinocyte growth factor 2

Recombinant Fgf10 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7170	KGF-2/FGF-10 Protein, Mouse	O35565 (S62-T209)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04887	FGF10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fgf10	NCBI	NCBI:2255

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