Fgf8 - fibroblast growth factor 8 Gene

Mus musculus

Also known as Aigf; Fgf-8; Fgf6c; HBGF-8

Gene ID: 14179 | Gene type: protein coding

About Fgf8

Summary

Predicted to enable signaling receptor binding activity. Involved in outflow tract septum morphogenesis. Acts upstream of or within several processes, including animal organ development; blood vessel morphogenesis; and embryonic morphogenesis. Predicted to be located in external side of plasma membrane. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including alimentary system; branchial arch; embryo ectoderm; embryo mesenchyme; and sensory organ. Used to study DiGeorge syndrome and tetralogy of Fallot. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 6 with or without anosmia and prostate carcinoma in situ. Orthologous to human FGF8 (Fibroblast Growth Factor 8). [provided by Alliance of Genome Resources, Apr 2022]

Fgf8 Products(7)

mRNA	Protein	Name
NM_001166361.2	NP_001159833.1	fibroblast growth factor 8 isoform 2 precursor
NM_001166362.2	NP_001159834.1	fibroblast growth factor 8 isoform 3 precursor
NM_001166363.2	NP_001159835.1	fibroblast growth factor 8 isoform 4 precursor
NM_001379139.1	NP_001366068.1	fibroblast growth factor 8 isoform 5 precursor
NM_001379140.1	NP_001366069.1	fibroblast growth factor 8 isoform 6 precursor
NM_001403100.1	NP_001390029.1	fibroblast growth factor 8 isoform 7 precursor
NM_010205.3	NP_034335.1	fibroblast growth factor 8 isoform 1 precursor

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within MAPK cascade	IMP IMP: Inferred from mutant phenotype	16720880	MGI
acts upstream of or within aorta morphogenesis	IGI IGI: Inferred from genetic interaction	21364285	MGI
acts upstream of apoptotic process	IGI IGI: Inferred from genetic interaction	16245339	MGI
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	16720880	MGI
acts upstream of or within blood vessel remodeling	IGI IGI: Inferred from genetic interaction	17000704	MGI
acts upstream of or within branching involved in blood vessel morphogenesis	IGI IGI: Inferred from genetic interaction	15996652	MGI
acts upstream of or within branching involved in salivary gland morphogenesis	IGI IGI: Inferred from genetic interaction	15042696	MGI
acts upstream of or within branching involved in salivary gland morphogenesis	IMP IMP: Inferred from mutant phenotype	15063181	MGI
acts upstream of or within branching involved in ureteric bud morphogenesis	IMP IMP: Inferred from mutant phenotype	16049111	MGI
acts upstream of or within cell fate commitment	IGI IGI: Inferred from genetic interaction	15809037	MGI
acts upstream of or within cell migration involved in mesendoderm migration	IMP IMP: Inferred from mutant phenotype	10421635	MGI
acts upstream of cell population proliferation	IGI IGI: Inferred from genetic interaction	16245339	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16720880	MGI
acts upstream of or within cell proliferation in forebrain	IMP IMP: Inferred from mutant phenotype	16613831	MGI
acts upstream of or within corticotropin hormone secreting cell differentiation	IDA IDA: Inferred from direct assay	9463347	MGI
acts upstream of or within determination of left/right symmetry	IMP IMP: Inferred from mutant phenotype	10411502	MGI
acts upstream of or within embryo development ending in birth or egg hatching	IMP IMP: Inferred from mutant phenotype	14623825	MGI
acts upstream of or within embryonic heart tube development	IMP IMP: Inferred from mutant phenotype	16720879	MGI
acts upstream of or within embryonic hindlimb morphogenesis	IGI IGI: Inferred from genetic interaction	16245339	MGI
acts upstream of or within embryonic neurocranium morphogenesis	IGI IGI: Inferred from genetic interaction	27395007	MGI
acts upstream of or within epithelial to mesenchymal transition involved in endocardial cushion formation	IDA IDA: Inferred from direct assay	21364285	MGI
involved in epithelial to mesenchymal transition involved in endocardial cushion formation	IMP IMP: Inferred from mutant phenotype	19509466	MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	9435295	MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16245339	MGI
acts upstream of or within forebrain dorsal/ventral pattern formation	IMP IMP: Inferred from mutant phenotype	16613831	MGI
acts upstream of or within forebrain morphogenesis	IMP IMP: Inferred from mutant phenotype	16613831	MGI
acts upstream of or within generation of neurons	IMP IMP: Inferred from mutant phenotype	16267092	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	16720879	MGI
acts upstream of or within heart looping	IMP IMP: Inferred from mutant phenotype	10411502	MGI
acts upstream of or within heart morphogenesis	IMP IMP: Inferred from mutant phenotype	16696966	MGI
acts upstream of or within inner ear morphogenesis	IGI IGI: Inferred from genetic interaction	15809037	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	16049111	MGI
acts upstream of or within larynx morphogenesis	IGI IGI: Inferred from genetic interaction	28177282	MGI
acts upstream of or within limb morphogenesis	IGI IGI: Inferred from genetic interaction	15328019	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	10411502	MGI
acts upstream of or within lung morphogenesis	IMP IMP: Inferred from mutant phenotype	10411502	MGI
acts upstream of or within male genitalia development	IDA IDA: Inferred from direct assay	12783783	MGI
acts upstream of or within mesodermal cell migration	IMP IMP: Inferred from mutant phenotype	10421635	MGI
acts upstream of or within midbrain-hindbrain boundary development	IMP IMP: Inferred from mutant phenotype	17601531	MGI
acts upstream of mitotic nuclear division	IDA IDA: Inferred from direct assay	12783783	MGI
acts upstream of or within negative regulation of apoptotic process	IGI IGI: Inferred from genetic interaction	16245339	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16613831	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	16245339	MGI
acts upstream of or within neural plate morphogenesis	IMP IMP: Inferred from mutant phenotype	16613831	MGI
acts upstream of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	16245339	MGI
acts upstream of organ growth	IGI IGI: Inferred from genetic interaction	19389367	MGI
acts upstream of organ growth	IMP IMP: Inferred from mutant phenotype	19389367	MGI
acts upstream of or within organ induction	IGI IGI: Inferred from genetic interaction	15741321	MGI
acts upstream of or within otic vesicle formation	IGI IGI: Inferred from genetic interaction	17601531	MGI
acts upstream of or within outflow tract morphogenesis	IGI IGI: Inferred from genetic interaction	21364285	MGI
involved in outflow tract septum morphogenesis	IGI IGI: Inferred from genetic interaction	20807544	MGI
acts upstream of or within pallium development	IMP IMP: Inferred from mutant phenotype	16613831	MGI
acts upstream of or within pharyngeal system development	IGI IGI: Inferred from genetic interaction	21364285	MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade	IGI IGI: Inferred from genetic interaction	24431450	MGI
acts upstream of or within positive regulation of G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	19307307	MGI
acts upstream of or within positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	9463347	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16720880	MGI
acts upstream of or within positive regulation of gene expression	IDA IDA: Inferred from direct assay	9244299	MGI
acts upstream of or within positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	9847236	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	10411502	MGI
acts upstream of or within positive regulation of mitotic nuclear division	IDA IDA: Inferred from direct assay	12783783	MGI
acts upstream of or within positive regulation of organ growth	IGI IGI: Inferred from genetic interaction	19389367	MGI
acts upstream of or within positive regulation of organ growth	IMP IMP: Inferred from mutant phenotype	19389367	MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	16399079	MGI
acts upstream of or within positive regulation of stem cell proliferation	IGI IGI: Inferred from genetic interaction	16245339	MGI
acts upstream of or within regulation of odontogenesis of dentin-containing tooth	IGI IGI: Inferred from genetic interaction	9244299	MGI
acts upstream of or within signal transduction involved in regulation of gene expression	IDA IDA: Inferred from direct assay	18462699	MGI
acts upstream of stem cell proliferation	IGI IGI: Inferred from genetic interaction	16245339	MGI
acts upstream of or within subpallium development	IMP IMP: Inferred from mutant phenotype	16613831	MGI
acts upstream of or within telencephalon development	IMP IMP: Inferred from mutant phenotype	16613831	MGI
acts upstream of or within thyroid gland development	IGI IGI: Inferred from genetic interaction	19389367	MGI
acts upstream of or within thyroid gland development	IMP IMP: Inferred from mutant phenotype	19389367	MGI
acts upstream of or within thyroid-stimulating hormone-secreting cell differentiation	IDA IDA: Inferred from direct assay	9463347	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

fibroblast growth factor 8

androgen-induced growth factor	fibroblast growth factor 6c
heparin-binding growth factor 8

Recombinant Fgf8 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7348	FGF-8c Protein, Mouse	P37237 (Q23-R268)	≥95%
HY-P70533	FGF-8b Protein, Human/Mouse	P55075-3/P37237-2 (Q23-R215)	≥95%
HY-P700070AF	Animal-Free FGF-8b Protein, Human/Mouse (His)	P55075-3/P37237-2 (Q33-R215)	≥95%
HY-P7348A	FGF-8c Protein, Mouse (His)	P37237 (Q23-R268)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04906	FGF8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fgf8	NCBI	NCBI:2253

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