Fgf9 - fibroblast growth factor 9 Gene

Mus musculus

Also known as Eks; Fgf4b

Gene ID: 14180 | Gene type: protein coding

About Fgf9

Summary

Predicted to enable Fibroblast Growth Factor receptor binding activity and growth factor activity. Involved in eye development. Acts upstream of or within several processes, including animal organ development; positive regulation of cell population proliferation; and positive regulation of signal transduction. Predicted to be located in basement membrane. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including alimentary system; central nervous system; cranium; genitourinary system; and sensory organ. Used to study lung cancer; multiple synostoses syndrome; and pleuropulmonary blastoma. Human ortholog(s) of this gene implicated in multiple synostoses syndrome. Orthologous to human FGF9 (Fibroblast Growth Factor 9). [provided by Alliance of Genome Resources, Apr 2022]

Fgf9 Products(1)

mRNA	Protein	Name
NM_013518.4	NP_038546.2	fibroblast growth factor 9

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of Sertoli cell proliferation	IMP IMP: Inferred from mutant phenotype	15229180	MGI
acts upstream of Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	16700629	MGI
acts upstream of activin receptor signaling pathway	IDA IDA: Inferred from direct assay	23034635	MGI
acts upstream of or within angiogenesis	IDA IDA: Inferred from direct assay	16778080	MGI
acts upstream of or within angiogenesis	IMP IMP: Inferred from mutant phenotype	16778080	MGI
acts upstream of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	18533146	MGI
acts upstream of cardiac muscle cell proliferation	IGI IGI: Inferred from genetic interaction	15621532	MGI
acts upstream of cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	15621532	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15229180	MGI
acts upstream of or within cell-cell signaling	IMP IMP: Inferred from mutant phenotype	15328018	MGI
acts upstream of or within chondrocyte differentiation	IGI IGI: Inferred from genetic interaction	17544391	MGI
acts upstream of or within chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	17544391	MGI
acts upstream of or within embryonic digestive tract development	IMP IMP: Inferred from mutant phenotype	16308329	MGI
acts upstream of or within embryonic limb morphogenesis	IMP IMP: Inferred from mutant phenotype	17576930	MGI
acts upstream of or within embryonic skeletal system development	IMP IMP: Inferred from mutant phenotype	17544391	MGI
acts upstream of epithelial cell proliferation	IDA IDA: Inferred from direct assay	16308329	MGI
acts upstream of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	16308329	MGI
involved in eye development	IMP IMP: Inferred from mutant phenotype	21858205	MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	15621532	MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15229180	MGI
acts upstream of or within inner ear morphogenesis	IMP IMP: Inferred from mutant phenotype	15328018	MGI
acts upstream of or within lung development	IDA IDA: Inferred from direct assay	16540513	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	11493531	MGI
acts upstream of or within lung-associated mesenchyme development	IMP IMP: Inferred from mutant phenotype	18533146	MGI
acts upstream of or within male gonad development	IMP IMP: Inferred from mutant phenotype	15229180	MGI
acts upstream of or within male sex determination	IGI IGI: Inferred from genetic interaction	16700629	MGI
acts upstream of or within male sex determination	IMP IMP: Inferred from mutant phenotype	16700629	MGI
acts upstream of mesenchymal cell proliferation	IDA IDA: Inferred from direct assay	16308329	MGI
acts upstream of mesenchymal cell proliferation	IMP IMP: Inferred from mutant phenotype	16308329	MGI
acts upstream of or within negative regulation of Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	16700629	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16308329	MGI
acts upstream of or within osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	17544391	MGI
acts upstream of or within positive regulation of activin receptor signaling pathway	IDA IDA: Inferred from direct assay	23034635	MGI
acts upstream of or within positive regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	18533146	MGI
acts upstream of or within positive regulation of cardiac muscle cell proliferation	IGI IGI: Inferred from genetic interaction	15621532	MGI
acts upstream of or within positive regulation of cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	15621532	MGI
acts upstream of or within positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	16185683	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IDA IDA: Inferred from direct assay	16308329	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	15229180	MGI
acts upstream of or within positive regulation of gene expression	IDA IDA: Inferred from direct assay	9847236	MGI
acts upstream of or within positive regulation of mesenchymal cell proliferation	IDA IDA: Inferred from direct assay	16308329	MGI
acts upstream of or within positive regulation of mesenchymal cell proliferation	IMP IMP: Inferred from mutant phenotype	16308329	MGI
acts upstream of or within positive regulation of smoothened signaling pathway	IDA IDA: Inferred from direct assay	16540513	MGI
acts upstream of or within positive regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	16778080	MGI
acts upstream of or within positive regulation of stem cell proliferation	IDA IDA: Inferred from direct assay	16308329	MGI
acts upstream of or within positive regulation of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	16308329	MGI
acts upstream of or within positive regulation of vascular endothelial growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17544391	MGI
acts upstream of or within protein import into nucleus	IMP IMP: Inferred from mutant phenotype	15229180	MGI
acts upstream of or within regulation of timing of cell differentiation	IMP IMP: Inferred from mutant phenotype	17544391	MGI
acts upstream of smoothened signaling pathway	IDA IDA: Inferred from direct assay	16540513	MGI
acts upstream of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	16778080	MGI
acts upstream of stem cell proliferation	IDA IDA: Inferred from direct assay	16308329	MGI
acts upstream of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	16308329	MGI
acts upstream of vascular endothelial growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17544391	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

fibroblast growth factor 9

FGF-9	GAF
HBGF-9	elbow knee synostosis
fibroblast growth factor 4b	glia-activating factor

Recombinant Fgf9 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7352	FGF-9 Protein, Mouse (His, solution)	P54130 (M1-S208)	≥95%
HY-P7352A	FGF-9 Protein, Mouse (N-His)	P54130 (A2-S208)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04907	FGF9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fgf9	NCBI	NCBI:2254

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