2. Gene
  3. Gab1 - growth factor receptor bound protein 2-associated protein 1 Gene

Gab1 - growth factor receptor bound protein 2-associated protein 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 14388 | Gene type: protein coding

About Gab1

Summary

Involved in positive regulation of cell migration by vascular endothelial growth factor signaling pathway. Acts upstream of or within several processes, including cell surface receptor signaling pathway; labyrinthine layer development; and positive regulation of MAP kinase activity. Located in cytoplasm. Is expressed in several structures, including brain; genitourinary system; heart; liver; and lung. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 26. Orthologous to human GAB1 (GRB2 associated binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Gab1 Products(2)

mRNA Protein Name
NM_001301298.1 NP_001288227.1 GRB2-associated-binding protein 1 isoform 1
NM_021356.2 NP_067331.2 GRB2-associated-binding protein 1 isoform 2
Protein Preferred Names Protein Names

GRB2-associated-binding protein 1

GRB2-associated binder 1

Gab1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Gab1 Q9QYY0 Grb2 Mus musculus Q60631
Y2H
10871282
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13404 Capmatinib 99.92% Yes
HY-13404C Capmatinib dihydrochloride hydrate 99.78% Yes
HY-13404B Capmatinib hydrochloride 99.60% Unkown
HY-13404A Capmatinib dihydrochloride / Unkown
Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05197 GAB1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gab1 NCBI NCBI:2549