BCDIN3D - BCDIN3 domain containing RNA methyltransferase Gene

Homo sapiens

Gene ID: 144233 | Gene type: protein coding

About BCDIN3D

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:49,836,043-49,843,106 (from NCBI)

This gene has 2 transcripts (splice variants), 181 orthologues and 1 paralogue. Ubiquitous expression in prostate (RPKM 3.3), lymph node (RPKM 3.0) and 25 other tissues.

Summary

This gene encodes an RNA methyltransferase which belongs to the rossmann fold methyltransferase family, and serves as a 5'-methylphosphate capping Enzyme that is specific for cytoplasmic histidyl tRNA. The encoded protein contains an S-adenosylmethionine binding domain and uses the methyl group donor, S-adenosylmethionine. This gene is overexpressed in breast Cancer cells, and is related to the tumorigenic phenotype and poor prognosis of breast Cancer. The encoded protein is thought to promote the cellular invasion of breast Cancer cells, by downregulating the expression of tumor suppressor miRNAs through the dimethylation of the 5-monophosphate of the corresponding precursor miRNAs. [provided by RefSeq, Apr 2017]

BCDIN3D Products(1)

mRNA	Protein	Name
NM_181708.3	NP_859059.1	RNA 5'-monophosphate methyltransferase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables O-methyltransferase activity	EXP EXP: Inferred from Experiment	23063121	GOA
enables RNA methyltransferase activity	IDA IDA: Inferred from direct assay	23063121	GOA
enables pre-miRNA binding	IDA IDA: Inferred from direct assay	33664453	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables small RNA 2'-O-methyltransferase activity	IDA IDA: Inferred from direct assay	23063121	GOA
enables tRNA methyltransferase activity	IDA IDA: Inferred from direct assay	28119416	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in RNA methylation	IDA IDA: Inferred from direct assay	33664453	GOA
involved in negative regulation of pre-miRNA processing	IDA IDA: Inferred from direct assay	23063121	GOA
involved in pre-miRNA processing	IDA IDA: Inferred from direct assay	33664453	GOA
involved in tRNA methylation	IDA IDA: Inferred from direct assay	28119416	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	23063121	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BCDIN3D Protein Structure

Bin3

0
100
200
292 a.a.

Protein Preferred Names

Protein Names

RNA 5'-monophosphate methyltransferase

BCDIN3 domain containing RNA methyltransfease

Related Diseases

Diseases

Alias

Malignant Essential Hypertension

Accelerated Essential Hypertension

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01405	BCDIN3D Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	BCDIN3D	VGNC	VGNC:26442
Mus musculus	BCDIN3D	MGD	MGI:1922534
Canis familiaris	BCDIN3D	VGNC	VGNC:38404
Macaca mulatta	BCDIN3D	VGNC	VGNC:70137
Rattus norvegicus	BCDIN3D	RGD	RGD:1306433
Felis catus	BCDIN3D	VGNC	VGNC:60081

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