Gbp2 - guanylate binding protein 2 Gene

Mus musculus

Gene ID: 14469 | Gene type: protein coding

About Gbp2

Summary

Predicted to enable several functions, including HSP90 protein binding activity; cytoskeletal protein binding activity; and guanyl ribonucleotide binding activity. Acts upstream of or within several processes, including cellular response to interferon-beta; cellular response to lipopolysaccharide; and defense response to Other organism. Located in cytoplasmic vesicle and symbiont-containing vacuole membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Orthologous to several human genes including GBP2 (guanylate binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Gbp2 Products(1)

mRNA	Protein	Name
NM_010260.1	NP_034390.1	guanylate-binding protein 2

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of innate immune response	IMP IMP: Inferred from mutant phenotype	24739961	MGI
acts upstream of or within adhesion of symbiont to host	IDA IDA: Inferred from direct assay	18025219	MGI
acts upstream of or within cellular response to interferon-beta	IDA IDA: Inferred from direct assay	19158679	MGI
involved in cellular response to interferon-beta	IDA IDA: Inferred from direct assay	18025219	MGI
acts upstream of or within cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	18025219	MGI
involved in cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	24715728	MGI
acts upstream of or within cellular response to type II interferon	IDA IDA: Inferred from direct assay	18025219	MGI
involved in cytolysis in another organism	IDA IDA: Inferred from direct assay	25774715	MGI
involved in cytolysis in another organism	IMP IMP: Inferred from mutant phenotype	24715728	MGI
acts upstream of or within defense response to Gram-positive bacterium	IDA IDA: Inferred from direct assay	18025219	MGI
involved in defense response to bacterium	IDA IDA: Inferred from direct assay	25774715	MGI
involved in defense response to bacterium	IMP IMP: Inferred from mutant phenotype	24715728	MGI
acts upstream of or within defense response to protozoan	IDA IDA: Inferred from direct assay	18025219	MGI
involved in positive regulation of AIM2 inflammasome complex assembly	IDA IDA: Inferred from direct assay	25774715	MGI
involved in positive regulation of pyroptotic inflammatory response	IDA IDA: Inferred from direct assay	25774715	MGI
involved in positive regulation of pyroptotic inflammatory response	IMP IMP: Inferred from mutant phenotype	24715728	MGI
involved in protein targeting	IDA IDA: Inferred from direct assay	27693356	MGI
acts upstream of or within response to bacterium	IEP IEP: Inferred from expression pattern	23012479	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	18025219	MGI
is active in symbiont cell surface	IDA IDA: Inferred from direct assay	27693356	MGI
located in symbiont-containing vacuole membrane	IDA IDA: Inferred from direct assay	18025219	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

guanylate-binding protein 2

GBP-2	GTP-binding protein 2
guanine nucleotide-binding protein 2	guanylate nucleotide binding protein 2
guanylate-binding protein 1	interferon-induced guanylate-binding protein 2
mGBP-2	mGBP2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05308	GBP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gbp2	NCBI	NCBI:2634

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