GBP2 - guanylate binding protein 2 Gene

Homo sapiens

Gene ID: 2634 | Gene type: protein coding

About GBP2

Cytogenetic location: 1p22.2 Genomic coordinates (GRCh38): 1:89,106,132-89,126,114 (from NCBI)

This gene has 4 transcripts (splice variants), 144 orthologues and 10 paralogues. Ubiquitous expression in appendix (RPKM 36.9), urinary bladder (RPKM 31.7) and 24 other tissues.

Summary

This gene belongs to the guanine-binding protein (GBP) family, which includes interferon-induced proteins that can bind to guanine nucleotides (GMP, GDP and GTP). The encoded protein is a GTPase which hydrolyzes GTP, predominantly to GDP. The protein may play a role as a marker of squamous cell carcinomas. [provided by RefSeq, Jul 2013]

GBP2 Products(1)

mRNA	Protein	Name
NM_004120.5	NP_004111.2	guanylate-binding protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables endopeptidase inhibitor activity	IDA IDA: Inferred from direct assay	31091448	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	21151871	GOA
enables molecular function inhibitor activity	IDA IDA: Inferred from direct assay	31091448	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18985028	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	21151871	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to interleukin-1	IEP IEP: Inferred from expression pattern	17266443	GOA
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	17266443	GOA
involved in cellular response to type II interferon	IDA IDA: Inferred from direct assay	17266443	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	31091448	GOA
involved in protein localization to nucleus	IDA IDA: Inferred from direct assay	21151871	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Golgi apparatus	IDA IDA: Inferred from direct assay	31091448	GOA
located in Golgi apparatus	IDA IDA: Inferred from direct assay	17266443	GOA
is active in Golgi membrane	IDA IDA: Inferred from direct assay	31091448	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	21151871	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17266443	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	17266443	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GBP2 Protein Structure

GBP

GBP_C

0
100
200
300
400
500
591 a.a.

Protein Preferred Names

Protein Names

guanylate-binding protein 2

GTP-binding protein 2

GBP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GBP2	P32456	GBP4	Homo sapiens	Q96PP9	Anti Tag CoIP	21151871
Intra	GBP2	P32456	GBP4	Homo sapiens	Q96PP9	BiFC	21151871
Intra	GBP2	P32456	GBP3	Homo sapiens	Q9H0R5	Anti Tag CoIP	28514442
Intra	GBP2	P32456	GBP3	Homo sapiens	Q9H0R5	Anti Tag CoIP	21151871
Intra	GBP2	P32456	GBP3	Homo sapiens	Q9H0R5	BiFC	21151871
Intra	GBP2	P32456	GBP3	Homo sapiens	Q9H0R5	Anti Tag CoIP	33961781
Intra	GBP2	P32456	GBP1	Homo sapiens	P32455	Anti Tag CoIP	21151871
Intra	GBP2	P32456	GBP1	Homo sapiens	P32455	BiFC	21151871
Intra	GBP2	P32456	GBP7	Homo sapiens	Q8N8V2	Anti Tag CoIP	33961781
Intra	GBP2	P32456	GBP2	Homo sapiens	P32456	Y2H	21151871
Intra	GBP2	P32456	GBP2	Homo sapiens	P32456	Anti Tag CoIP	21151871
Intra	GBP2	P32456	GBP7	Homo sapiens	Q8N8V2	Anti Tag CoIP	28514442
Intra	GBP2	P32456	GBP2	Homo sapiens	P32456	BiFC	21151871
Intra	GBP2	P32456	HSP90AA5P	Homo sapiens	Q58FG0	Anti Tag CoIP	33961781
Intra	GBP2	P32456	HSP90AA5P	Homo sapiens	Q58FG0	Anti Tag CoIP	28514442
Intra	GBP2	P32456	GBP5	Homo sapiens	Q96PP8	BiFC	21151871
Intra	GBP2	P32456	GBP5	Homo sapiens	Q96PP8	Anti Tag CoIP	21151871
Cross	GBP2	P32456	Q9WMX2-PRO_0000037548	Hepatitis C virus	Q9WMX2-PRO_0000037548	Pull Down	18985028

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GBP2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75787	GBP2 Protein, Human (HEK293, His)	AAH73163.1 (M1-C588)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05308	GBP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GBP2	RGD	RGD:621810
Mus musculus	GBP2	NCBI	NCBI:14469
Others	GBP2	NCBI

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