SERPINA12 - serpin family A member 12 Gene

Homo sapiens

Also known as OL-64

Gene ID: 145264 | Gene type: protein coding

About SERPINA12

Cytogenetic location: 14q32.13 Genomic coordinates (GRCh38): 14:94,487,279-94,517,844 (from NCBI)

This gene has 3 transcripts (splice variants), 88 orthologues, 36 paralogues and is associated with 1 phenotype. Restricted expression toward skin (RPKM 63.5).

Summary

Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to act upstream of or within negative regulation of gluconeogenesis; positive regulation of signal transduction; and regulation of lipid metabolic process. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

SERPINA12 Products(3)

mRNA	Protein	Name
NM_001304461.2	NP_001291390.1	serpin A12 precursor
NM_001382267.1	NP_001369196.1	serpin A12 precursor
NM_173850.4	NP_776249.1	serpin A12 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables molecular function inhibitor activity	IMP IMP: Inferred from mutant phenotype	23370777	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SERPINA12 Protein Structure

Serpin

0
100
200
300
414 a.a.

Protein Preferred Names

Protein Names

serpin A12

serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12

SERPINA12 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SERPINA12	Q8IW75	LAMB1	Homo sapiens	P07942	Anti Tag CoIP	33961781
Intra	SERPINA12	Q8IW75	LAMB1	Homo sapiens	P07942	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SERPINA12 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7419	Vaspin Protein, Human	Q8IW75 (L21-K414)	≥95%
HY-P71299	Vaspin Protein, Human (GST)	Q8IW75 (L21-K414)	≥95%
HY-P71300	Vaspin Protein, Human (HEK293, His)	Q8IW75 (L21-K414)	≥95%

Related Diseases

Diseases

Alias

Palmoplantar Keratoderma, Norrbotten Recessive Type

PPKNR	Hereditary Palmoplantar Keratoderma, Gamborg-Nielsen Type
Hereditary Palmoplantar Hyperkeratosis, Gamborg-Nielsen Type	Ppk, Gamborg-Nielsen Type
Keratoderma, Palmoplantar, Norrbotten Recessive Type

Carotid Stenosis

Carotid Artery Stenosis

Stenosis, Carotid Artery

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Amelogenesis Imperfecta

Ai	Congenital Enamel Hypoplasia
Al - [Amelogenesis Imperfecta]

Diabetes Mellitus

Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12698	SERPINA12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SERPINA12	VGNC	VGNC:77266
Felis catus	SERPINA12	VGNC	VGNC:65022
Mus musculus	SERPINA12	MGD	MGI:1915304
Rattus norvegicus	SERPINA12	RGD	RGD:708485
Canis familiaris	SERPINA12	VGNC	VGNC:51682
Others	SERPINA12	NCBI

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