LAMB1 - laminin subunit beta 1 Gene

Homo sapiens

Also known as CLM; LIS5

Gene ID: 3912 | Gene type: protein coding

About LAMB1

Cytogenetic location: 7q31.1 Genomic coordinates (GRCh38): 7:107,923,799-108,003,161 (from NCBI)

This gene has 37 transcripts (splice variants), 296 orthologues, 27 paralogues and is associated with 3 phenotypes. Broad expression in placenta (RPKM 75.7), fat (RPKM 65.2) and 23 other tissues.

Summary

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with Other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis. [provided by RefSeq, Aug 2011]

LAMB1 Products(1)

mRNA	Protein	Name
NM_002291.3	NP_002282.2	laminin subunit beta-1 precursor

LAMB1 Protein Structure

Laminin_N

Laminin_EGF

0
300
600
900
1200
1500
1786 a.a.

Protein Preferred Names

Protein Names

laminin subunit beta-1

laminin B1 chain

LAMB1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LAMB1	P07942	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	LAMB1	P07942	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	LAMB1	P07942	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	LAMB1	P07942	UBQLN1	Homo sapiens	Q9UMX0	Y2H Prey Pooling	32296183
Intra	LAMB1	P07942	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	LAMB1	P07942	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32296183
Intra	LAMB1	P07942	CD79A	Homo sapiens	P11912	Validated Y2H	32296183
Intra	LAMB1	P07942	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	LAMB1	P07942	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Cross	LAMB1	P07942	c5mbe7_cantt	Candida tropicalis	C5MBE7	Crosslink	26438063
Cross	LAMB1	P07942	c5mbe7_cantt	Candida tropicalis	C5MBE7	Affinity Chrom	26438063

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Lissencephaly 5

LIS5	Cobblestone Lissencephaly Without Muscular Or Ocular Involvement
Cobblestone Lissencephaly Without Muscular Or Eye Involvement	Lissencephaly Type 2 Without Muscular Or Eye Involvement
Lissencephaly Type 2 Without Muscular Or Ocular Involvement	Lissencephaly, Type 5

Cutis Laxa

Generalized Elastolysis	Loose Skin
Dermatolysis	Dermatomegaly
Cutis Laxa Syndrome

Band Heterotopia

Subcortical Band Heterotopia	Double Cortex Syndrome
Subcortical Laminar Heterotopia	Double Cortex
Band Heterotopia Of Brain	BH
Heco	Heterotopic Cortex
Familial Band Heterotopia	Dc
Dc Syndrome	Heterotopia, Subcortical Band
Sbh	Sclh
Bhy

Teratocarcinoma

Mixed Embryonal Carcinoma And Teratoma

Nephrotic Syndrome, Type 5, With Or Without Ocular Abnormalities

NPHS5	Nephrotic Syndrome Type 5
Nephrotic Syndrome Type 5, With Or Without Ocular Abnormalities	Nephrotic Syndrome 5 With Or Without Ocular Abnormalities
Nephrotic Syndrome, Type 5, With/Without Ocular Abnormalities

Junctional Epidermolysis Bullosa

Epidermolysis Bullosa, Junctional	Jeb
Epidermolysis Bullosa Atrophicans	Congenital Junctional Epidermolysis Bullosa
Epidermolysis Bullosa Junctional	Junctional Eb - [Epidermolysis Bullosa]
Jeb - [Junctional Epidermolysis Bullosa]	Lucidolytic Epidermolysis Bullosa

Embryonal Carcinoma

Embryonal Neoplasm	Embryonal Cancer
Primary Extragonadal Embryonal Carcinoma	Embryo Neoplasm
Carcinoma Embryonal	Cancer Embryonal
Carcinoma, Embryonal	Extragonadal Embryonal Carcinoma
Cancer, Embryonal

Supravalvular Aortic Stenosis

SVAS	Supravalvar Aortic Stenosis
Supravalvar Aortic Stenosis, Eisenberg Type	Aortic Supravalvular Stenosis
Aortic Stenosis, Supravalvular	Supra-Valvular Aortic Stenosis
Stenosis, Aortic Supravalvular	Stenosis, Supravalvular Aortic
Supravalvular Stenosis, Aortic	Aortic Stenosis Supravalvular

Hepatocellular Clear Cell Carcinoma

Clear Cell Carcinoma Of The Liver Cells	Hepatocellular Carcinoma, Clear Cell Type
Clear Cell Hepatocellular Carcinoma

Leiomyoma

Leiomyomatous Neoplasm	Leiomyomatous Tumor
Leiomyomas	Fibroid Tumor
Uterine Fibroids

Muscular Dystrophy

Muscular Dystrophies	Congenital Md
Congenital Muscular Dystrophy	Cmd
Mdc	Dystrophy, Muscular
Gower'S Muscular Dystrophy	Progressive Musclular Dystrophy
Pseudohypertrophic Atrophy	Pseudohypertrophic Muscle Paralysis
Pseudohypertrophic Muscular Atrophy	Pseudohypertrophic Muscular Dystrophy
Pseudohypertrophic Paralysis	Pseudomuscular Hypertrophy

Diffuse Mesangial Sclerosis

Familial Mesangial Sclerosis	Mesangial Sclerosis, Diffuse
Dms	Diffuse Isolated Mesangial Sclerosis
Isolated Diffuse Mesangial Sclerosis	Nephrotic Syndrome, Early Onset With Diffuse Mesangial Sclerosis

Leiomyomatosis

Lissencephaly

Pachygyria	Broad Gyri Of Cerebrum
Large Gyri Of Cerebrum	Macrogyria

Pierson Syndrome

Microcoria-Congenital Nephrotic Syndrome	Microcoria-Congenital Nephrosis Syndrome
PIERS	Microcoria - Congenital Nephrosis
Microcoria - Congenital Nephrotic Syndrome	PIERSS

Myopathy

Muscular Diseases

Myopathies

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Walker-Warburg Syndrome

Hard Syndrome	Walker-Warburg Congenital Muscular Dystrophy
Cerebroocular Dysplasia-Muscular Dystrophy Syndrome	Cod-Md Syndrome
Chemke Syndrome	Hydrocephalus, Agyria And Retinal Dysplasia
Cerebroocular Dysgenesis	Cerebroocular Dysplasia Muscular Dystrophy Syndrome
Hard +/- E Syndrome	Pagon Syndrome
Warburg Syndrome	Hydrocephalus, Agyria, And Retinal Dysplasia
Mddga	Muscular Dystrophy-Dystroglycanopathy , Type A
Muscular Dystrophy-Dystroglycanopathy [With Brain And Eye Anomalies], Type A	Hydrocephalus-Agyria-Retinal Dysplasia Syndrome
Wws	Dystrophy, Muscular, Dystroglycanopathy, Type A

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N1045	13-Keto-8(14)-Podocarpen-18-oic acid		/	Unkown
HY-N1607	18-Nor-4,15-dihydroxyabieta-8,11,13-trien-7-one		/	Unkown
HY-RS07502	LAMB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-N1294	Serratenediol		/	Unkown
HY-N3766	Diosbulbin G		/	Unkown
HY-N4013	Imbricatoloic acid		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LAMB1	VGNC	VGNC:68006
Bos taurus	LAMB1	VGNC	VGNC:30772
Rattus norvegicus	LAMB1	RGD	RGD:1306311
Macaca mulatta	LAMB1	VGNC	VGNC:74228
Canis familiaris	LAMB1	VGNC	VGNC:42567
Mus musculus	LAMB1	MGD	MGI:96743

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