CSRP1 - cysteine and glycine rich protein 1 Gene

Homo sapiens

Also known as CRP; CRP1; CSRP; CYRP; D1S181E; HEL-141; HEL-S-286

Gene ID: 1465 | Gene type: protein coding

About CSRP1

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:201,483,530-201,507,123 (from NCBI)

This gene has 19 transcripts (splice variants), 261 orthologues and 2 paralogues. Broad expression in prostate (RPKM 425.1), endometrium (RPKM 406.6) and 22 other tissues.

Summary

This gene encodes a member of the cysteine-rich protein (CSRP) family. This gene family includes a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this gene product occurs in proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]

CSRP1 Products(4)

mRNA	Protein	Name
NM_001193570.2	NP_001180499.1	cysteine and glycine-rich protein 1 isoform 3
NM_001193571.2	NP_001180500.1	cysteine and glycine-rich protein 1 isoform 1
NM_001193572.2	NP_001180501.1	cysteine and glycine-rich protein 1 isoform 1
NM_004078.3	NP_004069.1	cysteine and glycine-rich protein 1 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	26924529	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CSRP1 Protein Structure

LIM

0
100
193 a.a.

Protein Preferred Names

Protein Names

cysteine and glycine-rich protein 1

LIM-domain protein

CSRP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CSRP1	P21291	CA9	Homo sapiens	Q16790	Validated Y2H	32296183
Intra	CSRP1	P21291	CA9	Homo sapiens	Q16790	Y2H Array	32296183
Intra	CSRP1	P21291	CA9	Homo sapiens	Q16790	Y2H Prey Pooling	32296183
Intra	CSRP1	P21291	REEP1	Homo sapiens	Q9H902	Y2H Prey Pooling	32296183
Intra	CSRP1	P21291	REEP1	Homo sapiens	Q9H902	Validated Y2H	32296183
Intra	CSRP1	P21291	REEP1	Homo sapiens	Q9H902	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CSRP1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76298	CSRP1 Protein, Human (His)	P21291 (M1-E193)	≥95%

Related Diseases

Diseases

Alias

Endocardial Fibroelastosis

Endomyocardial Fibroelastosis	Elastomyofibrosis
EFE	Efe - [Endocardial Fibroelastosis]
Primary Endocardial Fibroelastosis	Fibroelastosis Cordis
Fetal Endocarditis	Fibroelastosis
Congenital Endocardial Fibroelastosis	Congenital Valvular Endocarditis

Mixed Hepatoblastoma

Mixed Epithelial And Mesenchymal Hepatoblastoma

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03258	CSRP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CSRP1	VGNC	VGNC:71527
Felis catus	CSRP1	VGNC	VGNC:61233
Canis familiaris	CSRP1	VGNC	VGNC:39675
Mus musculus	CSRP1	MGD	MGI:88549
Bos taurus	CSRP1	VGNC	VGNC:27773
Rattus norvegicus	CSRP1	RGD	RGD:62053
Others	CSRP1	NCBI

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