KCTD11 - potassium channel tetramerization domain containing 11 Gene

Homo sapiens

Also known as REN; KCASH1; C17orf36; REN/KCTD11

Gene ID: 147040 | Gene type: protein coding

About KCTD11

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,352,162-7,354,944 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 96 orthologues and 13 paralogues.

Summary

Enables identical protein binding activity. Predicted to be involved in positive regulation of neuron differentiation. Predicted to act upstream of or within negative regulation of neuroblast proliferation and negative regulation of smoothened signaling pathway. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

KCTD11 Products(2)

mRNA	Protein	Name
NM_001002914.3	NP_001002914.1	BTB/POZ domain-containing protein KCTD11 s
NM_001363642.1	NP_001350571.1	BTB/POZ domain-containing protein KCTD11 l

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	27152988	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCTD11 Protein Structure

BTB_2

0
100
200
232 a.a.

Protein Preferred Names

Protein Names

BTB/POZ domain-containing protein KCTD11

RING-type E3 ubiquitin transferase subunit KCTD11

Related Diseases

Diseases

Alias

Medulloblastoma

MDB	Cpnet
Localized Primitive Neuroectodermal Tumor	Classic Medulloblastoma
Medulloblastoma Predisposition Syndrome	Medulloblastoma, Somatic
Brain Medulloblastoma	Cns Pnet
Infratentorial Primitive Neuroectodermal Tumor	Neuroectodermal Tumors, Primitive
Medulloblastomas	Desmoplastic Medulloblastoma
Medulloblastoma, With Extensive Nodularity	Medulloblastoma Of Unspecified Site
Medullomyoblastoma Of Unspecified Site

Scalp-Ear-Nipple Syndrome

Finlay-Marks Syndrome	Sen Syndrome
SENS	Scalp Ear Nipple Syndrome
Hereditary Syndrome Of Lumpy Scalp, Odd Ears And Rudimentary Nipples	Hereditary Syndrome Of Lumpy Scalp, Odd Ears, And Rudimentary Nipples
Indian Childhood Cirrhosis

Progressive Myoclonus Epilepsy

Pme	Progressive Myoclonic Epilepsy
Myoclonic Epilepsies, Progressive	Unverricht-Lundborg Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07188	KCTD11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KCTD11	MGD	MGI:2448712
Macaca mulatta	KCTD11	VGNC	VGNC:99161
Rattus norvegicus	KCTD11	RGD	RGD:1307125
Bos taurus	KCTD11	VGNC	VGNC:30501

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