2. Gene
  3. NOTUM - notum, palmitoleoyl-protein carboxylesterase Gene

NOTUM - notum, palmitoleoyl-protein carboxylesterase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as hNOTUM

Gene ID: 147111 | Gene type: protein coding

About NOTUM

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:81,952,507-81,961,187 (from NCBI)

This gene has 4 transcripts (splice variants) and 254 orthologues. Restricted expression toward placenta (RPKM 82.6).

Summary

Enables palmitoleyl hydrolase activity. Involved in negative regulation of Wnt signaling pathway and protein depalmitoleylation. Acts upstream of or within bone development and regulation of bone mineralization. Predicted to be located in endoplasmic reticulum lumen and extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

NOTUM Products(1)

mRNA Protein Name
NM_178493.6 NP_848588.3 palmitoleoyl-protein carboxylesterase NOTUM precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables palmitoleyl hydrolase activity IDA
IDA: Inferred from direct assay
25731175 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within bone development IMP
IMP: Inferred from mutant phenotype
30622831 GOA
involved in negative regulation of Wnt signaling pathway IDA
IDA: Inferred from direct assay
25731175 GOA
involved in protein depalmitoleylation IDA
IDA: Inferred from direct assay
25731175 GOA
acts upstream of or within regulation of bone mineralization IDA
IDA: Inferred from direct assay
30622831 GOA
acts upstream of or within regulation of bone mineralization IMP
IMP: Inferred from mutant phenotype
30622831 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOTUM Protein Structure

PAE

PAE: Pectinacetylesterase (77 - 420)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 496 a.a.
Protein Preferred Names Protein Names

palmitoleoyl-protein carboxylesterase NOTUM

[Wnt protein] O-palmitoleoyl-L-serine hydrolase

NOTUM Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
NOTUM Q6P988 ZNF655 Homo sapiens Q8N720
Validated Y2H
32296183
Intra
NOTUM Q6P988 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
Intra
NOTUM Q6P988 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NOTUM Proteins

Cat. No. Product Name Accession Purity
HY-P79357 Notum Protein, Human (C330S, CHO, His) Q6P988 (S81-T451, C330S) ≥95%

Related Diseases

Diseases Alias
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-131034 LP-922056 Activator ≥98.0% Unkown
HY-122832 ABC99 Inhibitor 99.62% Unkown
HY-147519 ARUK3001185 Activator 99.16% Unkown
HY-142689 Carboxylesterase-IN-3 Inhibitor 98.01% Unkown
HY-142688 Carboxylesterase-IN-2 Inhibitor 99.83% Unkown
HY-148360 Notum pectinacetylesterase-1 / Unkown
HY-149818 8BTC Inhibitor / Unkown
HY-RS09454 NOTUM Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W171983 Notum-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta NOTUM VGNC VGNC:104636
Bos taurus NOTUM VGNC VGNC:106845
Mus musculus NOTUM MGD MGI:1924833
Felis catus NOTUM VGNC VGNC:63863
Canis familiaris NOTUM VGNC VGNC:43901
Rattus norvegicus NOTUM RGD RGD:1307119
Others NOTUM NCBI