NOTUM - notum, palmitoleoyl-protein carboxylesterase Gene

Homo sapiens

Also known as hNOTUM

Gene ID: 147111 | Gene type: protein coding

About NOTUM

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:81,952,507-81,961,187 (from NCBI)

This gene has 4 transcripts (splice variants) and 254 orthologues. Restricted expression toward placenta (RPKM 82.6).

Summary

Enables palmitoleyl hydrolase activity. Involved in negative regulation of Wnt signaling pathway and protein depalmitoleylation. Acts upstream of or within bone development and regulation of bone mineralization. Predicted to be located in endoplasmic reticulum lumen and extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

NOTUM Products(1)

mRNA	Protein	Name
NM_178493.6	NP_848588.3	palmitoleoyl-protein carboxylesterase NOTUM precursor

NOTUM Protein Structure

PAE

0
100
200
300
400
496 a.a.

Protein Preferred Names

Protein Names

palmitoleoyl-protein carboxylesterase NOTUM

[Wnt protein] O-palmitoleoyl-L-serine hydrolase

Recombinant NOTUM Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79357	Notum Protein, Human (C330S, CHO, His)	Q6P988 (S81-T451, C330S)	≥95%

Related Diseases

Diseases

Alias

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-131034	LP-922056	Activator	≥98.0%	Unkown
HY-122832	ABC99	Inhibitor	99.62%	Unkown
HY-147519	ARUK3001185	Activator	99.16%	Unkown
HY-142689	Carboxylesterase-IN-3	Inhibitor	98.01%	Unkown
HY-142688	Carboxylesterase-IN-2	Inhibitor	99.83%	Unkown
HY-148360	Notum pectinacetylesterase-1		/	Unkown
HY-149818	8BTC	Inhibitor	/	Unkown
HY-RS09454	NOTUM Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W171983	Notum-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NOTUM	VGNC	VGNC:104636
Bos taurus	NOTUM	VGNC	VGNC:106845
Mus musculus	NOTUM	MGD	MGI:1924833
Felis catus	NOTUM	VGNC	VGNC:63863
Canis familiaris	NOTUM	VGNC	VGNC:43901
Rattus norvegicus	NOTUM	RGD	RGD:1307119
Others	NOTUM	NCBI

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