Pdpn - podoplanin Gene

Mus musculus

Also known as E11; T1a; Gp38; OTS-8; T1alpha; RANDAM-2; T1-alpha

Gene ID: 14726 | Gene type: protein coding

About Pdpn

Summary

Predicted to enable chaperone binding activity; chemokine binding activity; and signaling receptor binding activity. Involved in several processes, including lymph node development; lymphatic endothelial cell fate commitment; and positive regulation of platelet aggregation. Acts upstream of or within several processes, including lung alveolus development; lymphangiogenesis; and prostaglandin metabolic process. Located in several cellular components, including external side of plasma membrane; lamellipodium; and ruffle. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; hemolymphoid system; and reproductive system. Orthologous to human PDPN (podoplanin). [provided by Alliance of Genome Resources, Apr 2022]

Pdpn Products(2)

mRNA	Protein	Name
NM_001290822.1	NP_001277751.1	podoplanin isoform 2 precursor
NM_010329.3	NP_034459.2	podoplanin isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables amino acid transmembrane transporter activity	IDA IDA: Inferred from direct assay	12032185	MGI
NOT enables folic acid transmembrane transporter activity	IDA IDA: Inferred from direct assay	12032185	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17616532	MGI
NOT enables water channel activity	IDA IDA: Inferred from direct assay	9651190	MGI
NOT enables water transmembrane transporter activity	IDA IDA: Inferred from direct assay	9651190	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin-mediated cell contraction	IDA IDA: Inferred from direct assay	25341788	MGI
NOT involved in amino acid transport	IDA IDA: Inferred from direct assay	12032185	MGI
involved in cell migration	IMP IMP: Inferred from mutant phenotype	10574709	MGI
acts upstream of or within cell population proliferation	IMP IMP: Inferred from mutant phenotype	16869965	MGI
acts upstream of or within cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	16869965	MGI
NOT involved in folic acid transport	IDA IDA: Inferred from direct assay	12032185	MGI
acts upstream of or within lung alveolus development	IMP IMP: Inferred from mutant phenotype	16869965	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	12654292	MGI
involved in lymph node development	IMP IMP: Inferred from mutant phenotype	25347465	MGI
acts upstream of or within lymphangiogenesis	IMP IMP: Inferred from mutant phenotype	12853470	MGI
involved in lymphatic endothelial cell fate commitment	IMP IMP: Inferred from mutant phenotype	20110424	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	25347465	MGI
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	25347465	MGI
acts upstream of or within positive regulation of cell motility	IMP IMP: Inferred from mutant phenotype	16869965	MGI
involved in positive regulation of platelet aggregation	IDA IDA: Inferred from direct assay	17616532	MGI
involved in positive regulation of platelet aggregation	IMP IMP: Inferred from mutant phenotype	20110424	MGI
acts upstream of or within prostaglandin metabolic process	IMP IMP: Inferred from mutant phenotype	16869965	MGI
acts upstream of or within regulation of G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	16869965	MGI
involved in regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	25347465	MGI
involved in regulation of myofibroblast contraction	IMP IMP: Inferred from mutant phenotype	25347465	MGI
involved in regulation of substrate adhesion-dependent cell spreading	IMP IMP: Inferred from mutant phenotype	25347465	MGI
acts upstream of or within signal transduction	IMP IMP: Inferred from mutant phenotype	16869965	MGI
NOT acts upstream of or within water transport	IDA IDA: Inferred from direct assay	9651190	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	23180825	MGI
located in filopodium	IDA IDA: Inferred from direct assay	10574709	MGI
located in lamellipodium	IDA IDA: Inferred from direct assay	10574709	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	9632596	MGI
located in ruffle	IDA IDA: Inferred from direct assay	10574709	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

podoplanin

PA2.26 antigen	aggrus
glycoprotein 38	transmembrane glycoprotein E11

Recombinant Pdpn Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71219	Podoplanin Protein, Mouse (HEK293, Fc)	Q62011 (G23-K133)	≥95%
HY-P73379	Podoplanin Protein, Mouse (sf9, His)	Q62011 (M1-K133)	≥95%
HY-P73704	Podoplanin Protein, Mouse (HEK293, His-Fc)	Q62011 (M1-L141)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-E70294	N-Acetylgalactosaminyltransferase 13		/	Unkown
HY-RS10288	PDPN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pdpn	NCBI	NCBI:10630
Rattus norvegicus	Pdpn	NCBI	NCBI:54320

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