2. Gene
  3. Lpar1 - lysophosphatidic acid receptor 1 Gene

Lpar1 - lysophosphatidic acid receptor 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Edg2; Kdt2; lpA1; vzg-1; Gpcr26

Gene ID: 14745 | Gene type: protein coding

About Lpar1

Chromosome 4: 58,435,255-58,553,898 reverse strand.GRCm39:CM000997.3

This gene has 8 transcripts (splice variants), 216 orthologues, 18 paralogues and is associated with 28 phenotypes. Ubiquitous expression in limb E14.5 (RPKM 2.9), colon adult (RPKM 17.1) and 24 other tissues.

Summary

Enables PDZ domain binding activity and lysophosphatidic acid receptor activity. Involved in several processes, including activation of Phospholipase C activity; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; and positive regulation of stress fiber assembly. Acts upstream of or within bleb assembly; positive regulation of MAPK cascade; and positive regulation of Rho protein signal transduction. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human LPAR1 (lysophosphatidic acid receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Lpar1 Products(3)

mRNA Protein Name
NM_172989.1 NP_766577.1 lysophosphatidic acid receptor 1 isoform 1
NM_010336.2 NP_034466.2 lysophosphatidic acid receptor 1 isoform 1
NM_001290486.1 NP_001277415.1 lysophosphatidic acid receptor 1 isoform 2

Lpar1 Protein Structure

7tmA_LPAR1_Edg2

7tmA_LPAR1_Edg2: cd15344 (49 - 321)

7tmA_LPAR1_Edg2

7tmA_LPAR1_Edg2: cd15344 (50 - 76)

7tmA_LPAR1_Edg2

7tmA_LPAR1_Edg2: cd15344 (83 - 108)

7tmA_LPAR1_Edg2

7tmA_LPAR1_Edg2: cd15344 (120 - 150)

7tmA_LPAR1_Edg2

7tmA_LPAR1_Edg2: cd15344 (161 - 181)

7tmA_LPAR1_Edg2

7tmA_LPAR1_Edg2: cd15344 (201 - 230)

7tmA_LPAR1_Edg2

7tmA_LPAR1_Edg2: cd15344 (250 - 280)

7tmA_LPAR1_Edg2

7tmA_LPAR1_Edg2: cd15344 (289 - 314)

  • 0
  • 100
  • 200
  • 300
  • 364 a.a.
Protein Preferred Names Protein Names

lysophosphatidic acid receptor 1

G-protein coupled receptor 26

LPA receptor 1

endothelial differentiation lysophosphatidic acid G-protein-coupled receptor 2

lysophosphatidic acid receptor Edg-2

rec1.3

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16039 AM095 Antagonist 99.72% Unkown
HY-15706 H2L 5765834 Antagonist 98.36% Unkown
HY-117444 ONO-9780307 Inhibitor 99.94% Unkown
HY-117959 TAK-615 Inhibitor 98.97% Unkown
HY-115450 ONO-0300302 Antagonist 99.43% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lpar1 NCBI NCBI:1902