Lpar1 - lysophosphatidic acid receptor 1 Gene

Mus musculus

Also known as Edg2; Kdt2; lpA1; vzg-1; Gpcr26

Gene ID: 14745 | Gene type: protein coding

About Lpar1

Chromosome 4: 58,435,255-58,553,898 reverse strand.GRCm39:CM000997.3

This gene has 8 transcripts (splice variants), 216 orthologues, 18 paralogues and is associated with 28 phenotypes. Ubiquitous expression in limb E14.5 (RPKM 2.9), colon adult (RPKM 17.1) and 24 other tissues.

Summary

Enables PDZ domain binding activity and lysophosphatidic acid receptor activity. Involved in several processes, including activation of Phospholipase C activity; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; and positive regulation of stress fiber assembly. Acts upstream of or within bleb assembly; positive regulation of MAPK cascade; and positive regulation of Rho protein signal transduction. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human LPAR1 (lysophosphatidic acid receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Lpar1 Products(3)

mRNA	Protein	Name
NM_172989.1	NP_766577.1	lysophosphatidic acid receptor 1 isoform 1
NM_010336.2	NP_034466.2	lysophosphatidic acid receptor 1 isoform 1
NM_001290486.1	NP_001277415.1	lysophosphatidic acid receptor 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	15755723	MGI
enables lysophosphatidic acid receptor activity	IDA IDA: Inferred from direct assay	8922387	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15755723	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	15755723	MGI
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	8922387	MGI
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	11040035	MGI
acts upstream of or within bleb assembly	IGI IGI: Inferred from genetic interaction	17135244	MGI
involved in negative regulation of neuron projection development	IDA IDA: Inferred from direct assay	11040035	MGI
involved in negative regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	9600933	MGI
acts upstream of or within positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	15755723	MGI
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	11040035	MGI
acts upstream of or within positive regulation of Rho protein signal transduction	IDA IDA: Inferred from direct assay	15755723	MGI
involved in positive regulation of Rho protein signal transduction	IDA IDA: Inferred from direct assay	11040035	MGI
involved in positive regulation of Rho protein signal transduction	IMP IMP: Inferred from mutant phenotype	9600933	MGI
involved in positive regulation of stress fiber assembly	IDA IDA: Inferred from direct assay	9600933	MGI
involved in regulation of cell shape	IDA IDA: Inferred from direct assay	8922387	MGI
involved in regulation of cell shape	IMP IMP: Inferred from mutant phenotype	9600933	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	8922387	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Lpar1 Protein Structure

7tmA_LPAR1_Edg2

0
100
200
300
364 a.a.

Protein Preferred Names

Protein Names

lysophosphatidic acid receptor 1

G-protein coupled receptor 26	LPA receptor 1
endothelial differentiation lysophosphatidic acid G-protein-coupled receptor 2	lysophosphatidic acid receptor Edg-2
rec1.3

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16039	AM095	Antagonist	99.72%	Unkown
HY-15706	H2L 5765834	Antagonist	98.36%	Unkown
HY-117444	ONO-9780307	Inhibitor	99.94%	Unkown
HY-117959	TAK-615	Inhibitor	98.97%	Unkown
HY-115450	ONO-0300302	Antagonist	99.43%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lpar1	NCBI	NCBI:1902

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