Nr3c1 - nuclear receptor subfamily 3, group C, member 1 Gene

Mus musculus

Also known as GR; Grl1; Grl-1

Gene ID: 14815 | Gene type: protein coding

About Nr3c1

Chromosome 18: 39,543,598-39,652,474 reverse strand.GRCm39:CM001011.3

This gene has 9 transcripts (splice variants), 280 orthologues, 8 paralogues and is associated with 67 phenotypes. Ubiquitous expression in bladder adult (RPKM 11.2), subcutaneous fat pad adult (RPKM 8.1) and 28 other tissues.

Summary

Enables several functions, including Glucocorticoid Receptor activity; identical protein binding activity; and protein kinase binding activity. Involved in positive regulation of pri-miRNA transcription by RNA polymerase II. Acts upstream of or within several processes, including gland development; Glucocorticoid Receptor signaling pathway; and regulation of cellular biosynthetic process. Located in cytosol; membrane; and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; lung; and sensory organ. Used to study primary hyperaldosteronism. Human ortholog(s) of this gene implicated in several diseases, including anorexia nervosa; lung disease (multiple); major depressive disorder; obesity; and renal cell carcinoma. Orthologous to human NR3C1 (nuclear receptor subfamily 3 group C member 1). [provided by Alliance of Genome Resources, Apr 2022]

Nr3c1 Products(5)

mRNA	Protein	Name
NM_001361209.1	NP_001348138.1	glucocorticoid receptor
NM_001361211.1	NP_001348140.1	glucocorticoid receptor
NM_008173.4	NP_032199.3	glucocorticoid receptor
NM_001361212.1	NP_001348141.1	glucocorticoid receptor
NM_001361210.1	NP_001348139.1	glucocorticoid receptor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15870285	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	7883868	MGI
enables nuclear glucocorticoid receptor activity	IDA IDA: Inferred from direct assay	7914432	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11751894	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	20371704	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	7883868	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within adrenal gland development	IMP IMP: Inferred from mutant phenotype	7628695	MGI
involved in astrocyte differentiation	IMP IMP: Inferred from mutant phenotype	29890290	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	29890290	MGI
acts upstream of or within glucocorticoid metabolic process	IMP IMP: Inferred from mutant phenotype	10509797	MGI
acts upstream of or within mammary gland duct morphogenesis	IMP IMP: Inferred from mutant phenotype	12198239	MGI
acts upstream of or within maternal behavior	IGI IGI: Inferred from genetic interaction	23071095	MGI
involved in microglia differentiation	IMP IMP: Inferred from mutant phenotype	29890290	MGI
involved in motor behavior	IMP IMP: Inferred from mutant phenotype	29890290	MGI
involved in neuroinflammatory response	IMP IMP: Inferred from mutant phenotype	29890290	MGI
acts upstream of or within nuclear receptor-mediated glucocorticoid signaling pathway	IDA IDA: Inferred from direct assay	15199138	MGI
involved in nuclear receptor-mediated glucocorticoid signaling pathway	IDA IDA: Inferred from direct assay	25510864	MGI
acts upstream of or within nuclear receptor-mediated glucocorticoid signaling pathway	IMP IMP: Inferred from mutant phenotype	7628695	MGI
involved in positive regulation of miRNA transcription	IDA IDA: Inferred from direct assay	25510864	MGI
acts upstream of or within positive regulation of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	10744634	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10224232	MGI
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	17081986	MGI
acts upstream of or within regulation of glucocorticoid biosynthetic process	IMP IMP: Inferred from mutant phenotype	7628695	MGI
acts upstream of or within regulation of gluconeogenesis	IMP IMP: Inferred from mutant phenotype	7628695	MGI
involved in synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	29890290	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	27686098	MGI
located in cytosol	IDA IDA: Inferred from direct assay	7914432	MGI
located in intracellular anatomical structure	IDA IDA: Inferred from direct assay	9237103	MGI
located in membrane	IDA IDA: Inferred from direct assay	9237103	MGI
located in nucleus	IDA IDA: Inferred from direct assay	7914432	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nr3c1 Protein Structure

GCR

NR_DBD_GR_PR

NR_LBD_GR

0
200
400
600
792 a.a.

Protein Preferred Names

Protein Names

glucocorticoid receptor

glucocorticoid receptor 1

glucocorticoid receptor subtype P

Nr3c1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80687	Glucocorticoid Receptor Antibody	WB, ICC/IF	Human, Mouse, Rat

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09544	NR3C1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09545	Nr3c1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09546	Nr3c1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nr3c1	NCBI	NCBI:2908

Name
Email *

	Sorry, but the email address you supplied was invalid.