BROX - BRO1 domain and CAAX motif containing Gene

Homo sapiens

Also known as C1orf58

Gene ID: 148362 | Gene type: protein coding

About BROX

This gene has 9 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in colon (RPKM 10.5), brain (RPKM 10.3) and 25 other tissues.

Summary

Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

BROX Products(6)

mRNA	Protein	Name
NM_001288579.2	NP_001275508.1	BRO1 domain-containing protein BROX isoform b
NM_001288580.2	NP_001275509.1	BRO1 domain-containing protein BROX isoform b
NM_001288581.2	NP_001275510.1	BRO1 domain-containing protein BROX isoform c
NM_001375661.1	NP_001362590.1	BRO1 domain-containing protein BROX isoform a
NM_001375758.1	NP_001362687.1	BRO1 domain-containing protein BROX isoform d
NM_144695.4	NP_653296.2	BRO1 domain-containing protein BROX isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22162750	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mitotic nuclear membrane reassembly	IMP IMP: Inferred from mutant phenotype	34818527	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nuclear envelope	IDA IDA: Inferred from direct assay	34818527	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BROX Protein Structure

BRO1

0
100
200
300
411 a.a.

Protein Preferred Names

Protein Names

BRO1 domain-containing protein BROX

Related Diseases

Diseases

Alias

Central Nervous System Sarcoma

Sarcoma Of The Cns

Developmental And Epileptic Encephalopathy 12

Epileptic Encephalopathy, Early Infantile, 12	DEE12
Eiee12	Early Infantile Epileptic Encephalopathy 12
Developmental And Epileptic Encephalopathy, 12	Encephalopathy, Epileptic, Early Infantile, Type 12

Breast Ductal Adenoma

Methemoglobinemia And Ambiguous Genitalia

METAG	Methemoglobinemia Type Iv
Isolated 17,20-Lyase Deficiency, Pure	Methemoglobinemia Due To Deficiency Of Cytochrome B5
Methemoglobinemia Type 4	Methemoglobinemia Type Iv, Formerly
Methemoglobinemia Due To Deficiency Of Cytochrome B5, Formerly	Pure Isolated 17,20-Lyase Deficiency
Methemoglobinemia, Type Iv

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01627	BROX Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	BROX	VGNC	VGNC:26571
Felis catus	BROX	VGNC	VGNC:60180
Canis familiaris	BROX	VGNC	VGNC:38532
Rattus norvegicus	BROX	RGD	RGD:1307161
Macaca mulatta	BROX	VGNC	VGNC:70399
Mus musculus	BROX	MGD	MGI:1918928

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