Ptpn6 - protein tyrosine phosphatase, non-receptor type 6 Gene

Mus musculus

Also known as me; hcp; Hcph; Ptp1C; SHP-1; 70Z-SHP; SH-PTP1; PTPTY-42

Gene ID: 15170 | Gene type: protein coding

About Ptpn6

Summary

Enables several functions, including phosphotyrosine residue binding activity; protein domain specific binding activity; and protein tyrosine Phosphatase activity. Involved in epididymis development; negative regulation of interleukin-6 production; and negative regulation of tumor necrosis factor production. Acts upstream of or within several processes, including hemopoiesis; negative regulation of protein phosphorylation; and regulation of lymphocyte activation. Located in cell-cell junction. Part of alpha-beta T cell receptor complex. Is expressed in several structures, including central nervous system; retina; and thymus primordium. Orthologous to human PTPN6 (protein tyrosine Phosphatase non-receptor type 6). [provided by Alliance of Genome Resources, Apr 2022]

Ptpn6 Products(2)

mRNA	Protein	Name
NM_001077705.2	NP_001071173.1	tyrosine-protein phosphatase non-receptor type 6 isoform b
NM_013545.3	NP_038573.2	tyrosine-protein phosphatase non-receptor type 6 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SH2 domain binding	IDA IDA: Inferred from direct assay	8632004	MGI
enables SH3 domain binding	IDA IDA: Inferred from direct assay	8632004	MGI
enables cell adhesion molecule binding	IPI IPI: Inferred from physical interaction	19948503	MGI
enables phosphotyrosine residue binding	IPI IPI: Inferred from physical interaction	10229828	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8632004	MGI
enables protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	8632004	MGI
enables protein tyrosine phosphatase activity	IMP IMP: Inferred from mutant phenotype	11745335	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within B cell receptor signaling pathway	IGI IGI: Inferred from genetic interaction	23509253	MGI
acts upstream of or within B cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9254656	MGI
acts upstream of MAPK cascade	IMP IMP: Inferred from mutant phenotype	9064344	MGI
acts upstream of T cell proliferation	IMP IMP: Inferred from mutant phenotype	9064344	MGI
acts upstream of T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9064344	MGI
involved in epididymis development	IMP IMP: Inferred from mutant phenotype	11266449	MGI
acts upstream of or within hematopoietic progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	24029230	MGI
acts upstream of or within intracellular signal transduction	IDA IDA: Inferred from direct assay	10229828	MGI
acts upstream of or within megakaryocyte development	IMP IMP: Inferred from mutant phenotype	23509158	MGI
acts upstream of or within natural killer cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	6971254	MGI
acts upstream of or within negative regulation of MAP kinase activity	IMP IMP: Inferred from mutant phenotype	9064344	MGI
acts upstream of or within negative regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	9064344	MGI
acts upstream of or within negative regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	9064344	MGI
acts upstream of or within negative regulation of T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9064344	MGI
acts upstream of or within negative regulation of humoral immune response mediated by circulating immunoglobulin	IMP IMP: Inferred from mutant phenotype	9254656	MGI
involved in negative regulation of inflammatory response to wounding	IDA IDA: Inferred from direct assay	27830702	MGI
involved in negative regulation of interleukin-6 production	IGI IGI: Inferred from genetic interaction	17954568	MGI
involved in negative regulation of mast cell activation involved in immune response	IDA IDA: Inferred from direct assay	10026201	MGI
acts upstream of or within negative regulation of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	9254656	MGI
involved in negative regulation of tumor necrosis factor production	IGI IGI: Inferred from genetic interaction	17954568	MGI
acts upstream of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	9254656	MGI
acts upstream of or within platelet aggregation	IMP IMP: Inferred from mutant phenotype	23509158	MGI
acts upstream of or within platelet formation	IGI IGI: Inferred from genetic interaction	23509158	MGI
acts upstream of or within positive regulation of cell adhesion mediated by integrin	IMP IMP: Inferred from mutant phenotype	23509158	MGI
acts upstream of or within protein dephosphorylation	IDA IDA: Inferred from direct assay	8632004	MGI
acts upstream of or within protein dephosphorylation	IMP IMP: Inferred from mutant phenotype	9064344	MGI
acts upstream of or within regulation of B cell differentiation	IMP IMP: Inferred from mutant phenotype	9254656	MGI
acts upstream of or within regulation of release of sequestered calcium ion into cytosol	IGI IGI: Inferred from genetic interaction	23509253	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of alpha-beta T cell receptor complex	IDA IDA: Inferred from direct assay	9064344	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	23793062	MGI
is active in cytoplasm	IDA IDA: Inferred from direct assay	27830702	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tyrosine-protein phosphatase non-receptor type 6

SH2 phosphatase 1	hematopoietic cell protein-tyrosine phosphatase
motheaten	protein-tyrosine phosphatase 1C

Recombinant Ptpn6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73649	SHP-1 Protein, Mouse (sf9, His-GST)	P29351-2 (A207-K597)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136657	SC-43		99.02%	Unkown
HY-RS11429	PTPN6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ptpn6	NCBI	NCBI:5777

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