GLIPR2 - GLI pathogenesis related 2 Gene

Homo sapiens

Also known as GAPR1; GAPR-1; C9orf19

Gene ID: 152007 | Gene type: protein coding

About GLIPR2

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:36,136,536-36,163,913 (from NCBI)

This gene has 5 transcripts (splice variants), 211 orthologues and 13 paralogues. Broad expression in lung (RPKM 23.8), appendix (RPKM 20.8) and 24 other tissues.

Summary

Enables protein homodimerization activity. Involved in positive regulation of ERK1 and ERK2 cascade; positive regulation of epithelial cell migration; and positive regulation of epithelial to mesenchymal transition. Located in Golgi membrane. [provided by Alliance of Genome Resources, Apr 2022]

GLIPR2 Products(6)

mRNA	Protein	Name
NM_001287010.2	NP_001273939.1	Golgi-associated plant pathogenesis-related protein 1 isoform b
NM_001287011.2	NP_001273940.1	Golgi-associated plant pathogenesis-related protein 1 isoform c
NM_001287012.2	NP_001273941.1	Golgi-associated plant pathogenesis-related protein 1 isoform d
NM_001287013.2	NP_001273942.1	Golgi-associated plant pathogenesis-related protein 1 isoform e
NM_001287014.2	NP_001273943.1	Golgi-associated plant pathogenesis-related protein 1 isoform f
NM_022343.4	NP_071738.1	Golgi-associated plant pathogenesis-related protein 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	15123429	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	23516513	GOA
involved in positive regulation of epithelial cell migration	IDA IDA: Inferred from direct assay	23516513	GOA
involved in positive regulation of epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	23516513	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi membrane	IDA IDA: Inferred from direct assay	11865038	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GLIPR2 Protein Structure

CAP

0
100
154 a.a.

Protein Preferred Names

Protein Names

Golgi-associated plant pathogenesis-related protein 1

17kD fetal brain protein

Related Diseases

Diseases

Alias

Necatoriasis

Miner'S Anaemia	Negro Cachexia
Dochmiasis	Ground Itch Disease
Brickmaker'S Chlorosis	Coolie Itch Anaemia
Cachexia Aquosa	Dew Itch Anaemia
Brickmaker'S Anaemia	Tunnel Worker'S Anaemia
Egyptian Anaemia	Tunnel Worker'S Disease
Miner'S Cachexia	Greisinger Disease
Tropical Chlorosis	Egyptian Chlorosis
Tunnel Anaemia	Dochmiosis
Necatorosis	African Cachexia
Water Itch Anaemia	Infection Due To Necator Americanus
St Gotthard Disease	Gotthard Tunnel Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P2260	Tat-beclin 1		99.93%	Unkown
HY-P2260C	Tat-beclin 1 scrambled TFA		98.54%	Unkown
HY-P2260B	Tat-beclin 1 scrambled		99.01%	Unkown
HY-P2260A	Tat-beclin 1 TFA		/	Unkown
HY-RS05479	GLIPR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GLIPR2	VGNC	VGNC:29405
Macaca mulatta	GLIPR2	VGNC	VGNC:81414
Canis familiaris	GLIPR2	VGNC	VGNC:41261
Mus musculus	GLIPR2	MGD	MGI:1917770
Rattus norvegicus	GLIPR2	RGD	RGD:1583669

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