SH3D19 - SH3 domain containing 19 Gene

Homo sapiens

Also known as EBP; EVE1; Kryn; Eve-1; SH3P19

Gene ID: 152503 | Gene type: protein coding

About SH3D19

Cytogenetic location: 4q31.3 Genomic coordinates (GRCh38): 4:151,120,281-151,325,605 (from NCBI)

This gene has 14 transcripts (splice variants), 261 orthologues and 12 paralogues. Ubiquitous expression in fat (RPKM 43.0), gall bladder (RPKM 40.6) and 23 other tissues.

Summary

This gene encodes a multiple SH3 domain-containing protein, which interacts with other proteins, such as EBP and members of ADAM family, via the SH3 domains. This protein may be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1 by EBP, and regulation of ADAM proteins in the signaling of EGFR-ligand shedding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

SH3D19 Products(14)

mRNA	Protein	Name
NM_001009555.4	NP_001009555.3	SH3 domain-containing protein 19 isoform 1
NM_001128923.2	NP_001122395.1	SH3 domain-containing protein 19 isoform 2
NM_001128924.2	NP_001122396.1	SH3 domain-containing protein 19 isoform 3
NM_001243349.2	NP_001230278.1	SH3 domain-containing protein 19 isoform 2
NM_001378121.1	NP_001365050.1	SH3 domain-containing protein 19 isoform 4
NM_001378122.1	NP_001365051.1	SH3 domain-containing protein 19 isoform 5
NM_001378123.1	NP_001365052.1	SH3 domain-containing protein 19 isoform 6
NM_001378124.1	NP_001365053.1	SH3 domain-containing protein 19 isoform 7
NM_001378126.1	NP_001365055.1	SH3 domain-containing protein 19 isoform 1
NM_001378127.1	NP_001365056.1	SH3 domain-containing protein 19 isoform 1
NM_001378128.1	NP_001365057.1	SH3 domain-containing protein 19 isoform 2
NM_001378129.1	NP_001365058.1	SH3 domain-containing protein 19 isoform 2
NM_001378130.1	NP_001365059.1	SH3 domain-containing protein 19 isoform 2
NM_001378131.1	NP_001365060.1	SH3 domain-containing protein 19 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables proline-rich region binding	IPI IPI: Inferred from physical interaction	15280379	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15280379	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	21834987	GOA
involved in positive regulation of membrane protein ectodomain proteolysis	IMP IMP: Inferred from mutant phenotype	15280379	GOA
involved in regulation of cell morphogenesis	IMP IMP: Inferred from mutant phenotype	21834987	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	15280379	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SH3D19 Protein Structure

SH3_2

SH3_1

SH3_9

SH3_1

SH3_9

0
200
400
600
790 a.a.

Protein Preferred Names

Protein Names

SH3 domain-containing protein 19

ADAM-binding protein Eve-1

Related Diseases

Diseases

Alias

Optic Atrophy 2

OPA2	Optic Atrophy, X-Linked
Optic Atrophy, Non-Leber Type, With Early Onset	Optic Atrophy 2, X-Linked
X-Linked Optic Atrophy 2	Early-Onset X-Linked Optic Atrophy
Non-Leber Type Optic Atrophy With Early-Onset	Optic Atrophy Type 2
Atrophy, Optic, Type 2

Chronic Intestinal Vascular Insufficiency

Chronic Mesenteric Ischemia

Cmi - Chronic Mesenteric Ischaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12834	SH3D19 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SH3D19	MGD	MGI:1350923
Canis familiaris	SH3D19	VGNC	VGNC:46122
Bos taurus	SH3D19	VGNC	VGNC:34570
Felis catus	SH3D19	VGNC	VGNC:65105
Rattus norvegicus	SH3D19	RGD	RGD:1304885
Macaca mulatta	SH3D19	VGNC	VGNC:77351

Name
Email *

	Sorry, but the email address you supplied was invalid.